    <SEC-DOCUMENT>0001390478-14-000075-index.html : 20141120
    <SEC-HEADER>0001390478-14-000075.hdr.sgml : 20141120
    <ACCEPTANCE-DATETIME>20141120162336
    ACCESSION NUMBER:		0001390478-14-000075
    CONFORMED SUBMISSION TYPE:	424B5
    PUBLIC DOCUMENT COUNT:		4
    FILED AS OF DATE:		20141120
    DATE AS OF CHANGE:		20141120

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Galena Biopharma, Inc.
    		CENTRAL INDEX KEY:			0001390478
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B5
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-188849
    		FILM NUMBER:		141239299

    	BUSINESS ADDRESS:
    		STREET 1:		4640 SW MACADAM AVENUE
    		STREET 2:		SUITE 270
    		CITY:			PORTLAND
    		STATE:			OR
    		ZIP:			97239
    		BUSINESS PHONE:		855 855 GALE

    	MAIL ADDRESS:
    		STREET 1:		4640 SW MACADAM AVENUE
    		STREET 2:		SUITE 270
    		CITY:			PORTLAND
    		STATE:			OR
    		ZIP:			97239

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RXi Pharmaceuticals Corp
    		DATE OF NAME CHANGE:	20110926

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	GALENA BIOPHARMA, INC.
    		DATE OF NAME CHANGE:	20110922

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RXI PHARMACEUTICALS CORP
    		DATE OF NAME CHANGE:	20110921
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B5
    <SEQUENCE>1
    <FILENAME>a424b5-lp.htm
    <DESCRIPTION>424B5
    <TEXT>
    Document 1 - file: a424b5-lp.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>modifieddocumentgalen_image1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: modifieddocumentgalen_image1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>modifieddocumentgalen_image3.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: modifieddocumentgalen_image3.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>pipeline13nov1copy.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: pipeline13nov1copy.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>