<SEC-DOCUMENT>0001193125-15-089474-index.html : 20150312
<SEC-HEADER>0001193125-15-089474.hdr.sgml : 20150312
<ACCEPTANCE-DATETIME>20150312172509
ACCESSION NUMBER:		0001193125-15-089474
CONFORMED SUBMISSION TYPE:	424B2
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20150312
DATE AS OF CHANGE:		20150312

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Galena Biopharma, Inc.
		CENTRAL INDEX KEY:			0001390478
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B2
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-188849
		FILM NUMBER:		15696898

	BUSINESS ADDRESS:	
		STREET 1:		4640 SW MACADAM AVENUE
		STREET 2:		SUITE 270
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97239
		BUSINESS PHONE:		855 855 GALE

	MAIL ADDRESS:	
		STREET 1:		4640 SW MACADAM AVENUE
		STREET 2:		SUITE 270
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97239

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RXi Pharmaceuticals Corp
		DATE OF NAME CHANGE:	20110926

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GALENA BIOPHARMA, INC.
		DATE OF NAME CHANGE:	20110922

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RXI PHARMACEUTICALS CORP
		DATE OF NAME CHANGE:	20110921
</SEC-HEADER>
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<TYPE>424B2
<SEQUENCE>1
<FILENAME>d888300d424b2.htm
<DESCRIPTION>424B2
<TEXT>
Document 1 - file: d888300d424b2.htm

</DOCUMENT>
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<SEQUENCE>2
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<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g888300g20f37.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g888300g25j45.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g888300g25j45.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g888300g79y59.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g888300g79y59.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g888300g88d27.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g888300g88d27.jpg

</DOCUMENT>
</SEC-DOCUMENT>