<SEC-DOCUMENT>0001193125-16-727706-index.html : 20160930
<SEC-HEADER>0001193125-16-727706.hdr.sgml : 20160930
<ACCEPTANCE-DATETIME>20160930170114
ACCESSION NUMBER:		0001193125-16-727706
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20160930
DATE AS OF CHANGE:		20160930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Galena Biopharma, Inc.
		CENTRAL INDEX KEY:			0001390478
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-213908
		FILM NUMBER:		161913464

	BUSINESS ADDRESS:	
		STREET 1:		4640 SW MACADAM AVENUE
		STREET 2:		SUITE 270
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97239
		BUSINESS PHONE:		855 855 GALE

	MAIL ADDRESS:	
		STREET 1:		4640 SW MACADAM AVENUE
		STREET 2:		SUITE 270
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97239

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RXi Pharmaceuticals Corp
		DATE OF NAME CHANGE:	20110926

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GALENA BIOPHARMA, INC.
		DATE OF NAME CHANGE:	20110922

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RXI PHARMACEUTICALS CORP
		DATE OF NAME CHANGE:	20110921
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>d268898ds3.htm
<DESCRIPTION>FORM S-3
<TEXT>
Document 1 - file: d268898ds3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>d268898dex51.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 2 - file: d268898dex51.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>3
<FILENAME>d268898dex232.htm
<DESCRIPTION>EX-23.2
<TEXT>
Document 3 - file: d268898dex232.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g268898bcpg01.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g268898bcpg01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g268898covpg01.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g268898covpg01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g268898g10a41.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: g268898g10a41.jpg

</DOCUMENT>
</SEC-DOCUMENT>