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Warrants | 6 Months Ended | 12 Months Ended
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Jun. 30, 2017 | Dec. 31, 2016
Warrants and Rights Note Disclosure [Abstract] |  |
Warrants | 7. Warrants The following is a summary of warrant activity for the six months ended June 30, 2017 (in thousands):
Warrant Issuance |  | Outstanding, December 31, 2016 |  |  | Granted |  |  | Exercised |  |  | Expired |  |  | Outstanding, June 30 2017 |  |  | Expiration |
February 2017 |  |  | — |  |  |  | 17,000 |  |  |  | — |  |  |  | — |  |  |  | 17,000 |  |  |  | February 2022 |
July 2016 |  |  | 700 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 700 |  |  |  | January 2022 |
January 2016 |  |  | 682 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 682 |  |  |  | January 2021 |
March 2015 |  |  | 700 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 700 |  |  |  | March 2020 |
September 2013 |  |  | 199 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 199 |  |  |  | September 2018 |
December 2012 |  |  | 152 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 152 |  |  |  | December 2017 |
April 2011 |  |  | 13 |  |  |  | — |  |  |  | — |  |  |  | (13 | ) |  |  | — |  |  |  | April 2017 |
Other |  |  | 124 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 124 |  |  |  | November 2021 |
|  |  | 2,570 |  |  |  | 17,000 |  |  |  | — |  |  |  | (13 | ) |  |  | 19,557 |  |  |  |  |
Warrants consist of warrants potentially settleable in cash, which are liability-classified warrants, and equity-classified warrants. Warrants classified as liabilities Liability-classified warrants consist of warrants to purchase common stock issued in connection with equity financings in February 2017, July 2016, January 2016, March 2015, September 2013, December 2012, and April 2011. These warrants are potentially settleable in cash and were determined not to be indexed to our common stock. Most of our warrants have a provision allowing the holders of warrants to require us to make a cash payment in the event we engage in a Fundamental Transaction. The term Fundamental Transaction is defined in each warrant agreement governing the applicable class of warrants. The cash payment is based upon a Black-Scholes analysis of the remaining value of the warrant at the time the Fundamental Transaction is effectuated. In August 2017, a holder of warrants under the warrant agreement dated February 13, 2017 has asserted that the Proposed Merger of SELLAS constitutes a Fundamental Transaction. The Company is in process of determining the merits of the assertion. The estimated fair value of outstanding warrants accounted for as liabilities is determined at each balance sheet date. Any decrease or increase in the estimated fair value of the warrant liability since the most recent balance sheet date is recorded in the condensed consolidated statement of operations as other income (expense). The fair value of the warrants is estimated using an appropriate pricing model with the following inputs:
As of June 30, 2017 |
Warrant Issuance |  | Outstanding (in thousands) |  |  | Strike price (per share) |  |  | Expected term (years) |  |  | Volatility % |  |  | Risk-free rate % |
February 2017 |  |  | 17,000 |  |  | $ | 1.10 |  |  |  | 4.62 |  |  |  | 136.07 | % |  |  | 1.83 | %
July 2016 |  |  | 700 |  |  | $ | 13.00 |  |  |  | 4.04 |  |  |  | 144.12 | % |  |  | 1.73 | %
January 2016 |  |  | 682 |  |  | $ | 28.40 |  |  |  | 3.53 |  |  |  | 150.15 | % |  |  | 1.64 | %
March 2015 |  |  | 700 |  |  | $ | 41.60 |  |  |  | 2.72 |  |  |  | 168.20 | % |  |  | 1.50 | %
September 2013 |  |  | 199 |  |  | $ | 50.00 |  |  |  | 1.22 |  |  |  | 100.31 | % |  |  | 1.27 | %
December 2012 |  |  | 152 |  |  | $ | 10.32 |  |  |  | 0.48 |  |  |  | 49.17 | % |  |  | 1.13 | %
As of December 31, 2016 |
Warrant Issuance |  | Outstanding (in thousands) |  |  | Strike price (per share) |  |  | Expected term (years) |  |  | Volatility % |  |  | Risk-free rate % |
July 2016 |  |  | 700 |  |  | $ | 13.00 |  |  |  | 4.54 |  |  |  | 117.82 | % |  |  | 1.82 | %
January 2016 |  |  | 682 |  |  | $ | 28.40 |  |  |  | 4.03 |  |  |  | 120.38 | % |  |  | 1.71 | %
March 2015 |  |  | 700 |  |  | $ | 41.60 |  |  |  | 3.22 |  |  |  | 131.46 | % |  |  | 1.52 | %
September 2013 |  |  | 199 |  |  | $ | 50.00 |  |  |  | 1.72 |  |  |  | 164.01 | % |  |  | 1.10 | %
December 2012 |  |  | 152 |  |  | $ | 31.60 |  |  |  | 0.98 |  |  |  | 204.55 | % |  |  | 0.84 | %
April 2011 |  |  | 13 |  |  | $ | 13.00 |  |  |  | 0.31 |  |  |  | 103.79 | % |  |  | 0.53 | %
The expected volatility assumptions are based on the Company’s implied volatility in combination with the implied volatilities of similar publicly traded entities. The expected life assumption is based on the remaining contractual terms of the warrants. The risk-free rate is based on the zero coupon rates in effect at the time of valuation. The dividend yield used in the pricing model is zero, because the Company has no present intention to pay cash dividends. The changes in fair value of the warrant liability for the six months ended June 30, 2017 were as follows (in thousands):
Warrant Issuance |  | Warrant liability, December 31, 2016 |  |  | Fair value of warrants granted |  |  | Fair value of warrants exercised |  |  | Change in fair value of warrants |  |  | Warrant liability, June 30, 2017 |
February 2017 |  | $ | — |  |  | $ | 10,357 |  |  | $ | — |  |  | $ | (2,345 | ) |  | $ | 8,012 |
July 2016 |  |  | 753 |  |  |  | — |  |  |  | — |  |  |  | (540 | ) |  |  | 213 |
January 2016 |  |  | 529 |  |  |  | — |  |  |  | — |  |  |  | (375 | ) |  |  | 154 |
March 2015 |  |  | 432 |  |  |  | — |  |  |  | — |  |  |  | (301 | ) |  |  | 131 |
September 2013 |  |  | 81 |  |  |  | — |  |  |  | — |  |  |  | (81 | ) |  |  | — |
December 2012 |  |  | 65 |  |  |  | — |  |  |  | — |  |  |  | (65 | ) |  |  | — |
April 2011 |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
|  | $ | 1,860 |  |  | $ | 10,357 |  |  | $ | — |  |  | $ | (3,707 | ) |  | $ | 8,510 |
Warrants classified as equity Equity-classified warrants consist of warrants issued in connection with consulting services provided to us. Additionally, on May 8, 2013 as a part of a previous loan financing, we granted Oxford Financial LLC warrants to purchase 9,109 shares of common stock at an exercise price of $49.40 per share, which equaled the 20-day average market price of our common stock prior to the date of the grant. The warrants were valued using the Black Scholes model. The fair value assumptions for the grant included a volatility of 75.34%, expected term of seven years, risk free rate of 1.20%, and a dividend rate of 0.00%. The fair value of the warrants granted was $38.60 per share. These warrants are recorded in equity at fair value upon issuance, and not as liabilities, and are not subject to adjustment to fair value in subsequent reporting periods. In 2016, the Company issued warrants to purchase 100,000 shares of common stock to the holder of the Debenture. The holder received 50,000 warrants upon the closing on the sale of the Debenture at an exercise price of $30.20, maturing 5 years from issuance, and in accordance with the terms of the amendment agreement, the exercise price of the warrant was reduced to $8.60 per share. The fair value assumptions for the grant included a volatility of 77.13%, expected term of 5.5 years, risk free rate of 1.26%, and a dividend rate of 0.00%. Additionally, the holder received 50,000 warrants upon the Company’s public company announcement of the interim analysis on June 29, 2016 at an exercise price of $8.60. The fair value assumptions for the grant included a volatility of 106.63%, expected term of 5.5 years, risk free rate of 1.35%, and a dividend rate of 0.00%. In addition to the warrants issued to the holder of the Debenture there are 15,000 outstanding warrants issued to service providers with a weighted average exercise price of $79.40 as of June 30, 2017 and December 31, 2016. These warrants are recorded in equity at fair value upon issuance, and not as liabilities, and are not subject to adjustment to fair value in subsequent reporting periods. | 8. Warrants The following is a summary of warrant activity for the years ended December 31, 2016 and 2015 (in thousands):
Warrant Issuance |  | Outstanding, December 31, 2015 |  |  | Granted |  |  | Exercised |  |  | Expired |  |  | Outstanding, December 31, 2016 |  |  | Expiration |
July 2016 |  |  | — |  |  |  | 700 |  |  |  | — |  |  |  | — |  |  |  | 700 |  |  |  | January 2022 |
January 2016 |  |  | — |  |  |  | 682 |  |  |  | — |  |  |  | — |  |  |  | 682 |  |  |  | January 2021 |
March 2015 |  |  | 700 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 700 |  |  |  | March 2020 |
September 2013 |  |  | 199 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 199 |  |  |  | September 2018 |
December 2012 |  |  | 152 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 152 |  |  |  | December 2017 |
April 2011 |  |  | 31 |  |  |  | — |  |  |  | (18 | ) |  |  | — |  |  |  | 13 |  |  |  | April 2017 |
March 2011 |  |  | 9 |  |  |  | — |  |  |  | (1 | ) |  |  | (8 | ) |  |  | — |  |  |  | March 2016 |
March 2010 |  |  | 1 |  |  |  | — |  |  |  | — |  |  |  | (1 | ) |  |  | — |  |  |  | March 2016 |
Other |  |  | 24 |  |  |  | 100 |  |  |  | — |  |  |  | — |  |  |  | 124 |  |  |  | November 2021 |
|  |  | 1,116 |  |  |  | 1,482 |  |  |  | (19 | ) |  |  | (9 | ) |  |  | 2,570 |  |  |  |  |
Warrant Issuance |  | Outstanding, January 1, 2015 |  |  | Granted |  |  | Exercised |  |  | Expired |  |  | Outstanding, December 31, 2015 |  |  | Expiration |
March 2015 |  |  | — |  |  |  | 700 |  |  |  | — |  |  |  | — |  |  |  | 700 |  |  |  | March 2020 |
September 2013 |  |  | 199 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 199 |  |  |  | September 2018 |
December 2012 |  |  | 152 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 152 |  |  |  | December 2017 |
April 2011 |  |  | 31 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 31 |  |  |  | April 2017 |
March 2011 |  |  | 9 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 9 |  |  |  | March 2016 |
March 2010 |  |  | 1 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1 |  |  |  | March 2016 |
Other |  |  | 36 |  |  |  | — |  |  |  | — |  |  |  | (12 | ) |  |  | 24 |  |  |  | November 2021 |
|  |  | 428 |  |  |  | 700 |  |  |  | — |  |  |  | (12 | ) |  |  | 1,116 |  |  |  |  |
Warrants consist of warrants potentially settleable in cash, which are liability-classified warrants, and equity-classified warrants. Warrants classified as liabilities Liability-classified warrants consist of warrants to purchase common stock issued in connection with equity financings in July 2016, January 2016, March 2015, September 2013, December 2012, April 2011, March 2011, March 2010 and August 2009. These warrants are potentially settleable in cash and were determined not to be indexed to our common stock. The estimated fair value of outstanding warrants accounted for as liabilities is determined at each balance sheet date. Any decrease or increase in the estimated fair value of the warrant liability since the most recent balance sheet date is recorded in the consolidated statement of operations as other income (expense). The fair value of the warrants is estimated using an appropriate pricing model with the following inputs:
As of December 31, 2016 |
Warrant Issuance |  | Outstanding |  |  | Strike price |  |  | Expected term |  |  | Volatility % |  |  | Risk-free rate % |
July 2016 |  |  | 700 |  |  | $ | 13.00 |  |  |  | 4.54 |  |  |  | 117.82 | % |  |  | 1.82 | %
January 2016 |  |  | 682 |  |  | $ | 28.40 |  |  |  | 4.03 |  |  |  | 120.38 | % |  |  | 1.71 | %
March 2015 |  |  | 700 |  |  | $ | 41.60 |  |  |  | 3.22 |  |  |  | 131.46 | % |  |  | 1.52 | %
September 2013 |  |  | 199 |  |  | $ | 50.00 |  |  |  | 1.72 |  |  |  | 164.01 | % |  |  | 1.10 | %
December 2012 |  |  | 152 |  |  | $ | 31.60 |  |  |  | 0.98 |  |  |  | 204.55 | % |  |  | 0.84 | %
April 2011 |  |  | 13 |  |  | $ | 13.00 |  |  |  | 0.31 |  |  |  | 103.79 | % |  |  | 0.53 | %
As of December 31, 2015 |
Warrant Issuance |  | Outstanding |  |  | Strike price |  |  | Expected term |  |  | Volatility % |  |  | Risk-free rate % |
March 2015 |  |  | 700 |  |  | $ | 41.60 |  |  |  | 4.22 |  |  |  | 75.85 | % |  |  | 1.58 | %
September 2013 |  |  | 199 |  |  | $ | 50.00 |  |  |  | 2.72 |  |  |  | 74.70 | % |  |  | 1.24 | %
December 2012 |  |  | 152 |  |  | $ | 31.60 |  |  |  | 1.98 |  |  |  | 76.37 | % |  |  | 1.05 | %
April 2011 |  |  | 31 |  |  | $ | 13.00 |  |  |  | 1.31 |  |  |  | 65.60 | % |  |  | 0.77 | %
March 2011 |  |  | 9 |  |  | $ | 13.00 |  |  |  | 0.18 |  |  |  | 47.98 | % |  |  | — | %
March 2010 |  |  | 1 |  |  | $ | 40.04 |  |  |  | 0.24 |  |  |  | 71.41 | % |  |  | — | %
The Company’s expected volatility is based on a combination of implied volatilities of similar publicly traded entities. The expected life assumption is based on the remaining contractual terms of the warrants. The risk-free rate is based on the zero coupon rates in effect at the time of valuation. The dividend yield used in the pricing model is zero, because the company has no present intention to pay cash dividends. The changes in fair value of the warrant liability for the years ended December 31, 2016 and 2015 were as follows (in thousands):
Warrant Issuance |  | Warrant liability, December 31, 2015 |  |  | Fair value of warrants granted |  |  | Fair value of warrants exercised |  |  | Change in fair value of warrants |  |  | Warrant liability, December 31, 2016 |
July 2016 |  | $ | — |  |  | $ | 4,296 |  |  | $ | — |  |  | $ | (3,543 | ) |  | $ | 753 |
January 2016 |  |  | — |  |  |  | 5,590 |  |  |  | — |  |  |  | (5,061 | ) |  |  | 529 |
March 2015 |  |  | 10,337 |  |  |  | — |  |  |  | — |  |  |  | (9,905 | ) |  |  | 432 |
September 2013 |  |  | 1,933 |  |  |  | — |  |  |  | — |  |  |  | (1,852 | ) |  |  | 81 |
December 2012 |  |  | 1,565 |  |  |  | — |  |  |  | — |  |  |  | (1,500 | ) |  |  | 65 |
April 2011 |  |  | 537 |  |  |  | — |  |  |  | (278 | ) |  |  | (259 | ) |  |  | — |
March 2011 |  |  | 144 |  |  |  | — |  |  |  | (46 | ) |  |  | (98 | ) |  |  | — |
March 2010 |  |  | 2 |  |  |  | — |  |  |  | — |  |  |  | (2 | ) |  |  | — |
|  | $ | 14,518 |  |  | $ | 9,886 |  |  | $ | (324 | ) |  | $ | (22,220 | ) |  | $ | 1,860 |
Warrant Issuance |  | Warrant liability, January 1, 2015 |  |  | Fair value of warrants granted |  |  | Fair value of warrants exercised |  |  | Change in fair value of warrants |  |  | Warrant liability, December 31, 2015 |
March 2015 |  |  | — |  |  |  | 10,296 |  |  |  | — |  |  |  | 41 |  |  |  | 10,337 |
September 2013 |  |  | 2,560 |  |  |  | — |  |  |  | — |  |  |  | (627 | ) |  |  | 1,933 |
December 2012 |  |  | 2,027 |  |  |  | — |  |  |  | — |  |  |  | (462 | ) |  |  | 1,565 |
April 2011 |  |  | 625 |  |  |  | — |  |  |  | — |  |  |  | (88 | ) |  |  | 537 |
March 2011 |  |  | 144 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 144 |
March 2010 |  |  | 2 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 2 |
|  |  | 5,358 |  |  |  | 10,296 |  |  |  | — |  |  |  | (1,136 | ) |  |  | 14,518 |
Warrants classified as equity Equity-classified warrants consist of warrants issued in connection with consulting services provided to us. Additionally, on May 8, 2013 as a part of our Loan financing, we granted Oxford Financial LLC warrants to purchase 9,109 shares of common stock at an exercise price of $49.40 per share, which equaled the 20-day average market price of our common stock prior to the date of the grant. The warrants were valued using the Black Scholes model. The fair value assumptions for the grant included a volatility of 75.34%, expected term of seven years, risk free rate of 1.20%, and a dividend rate of 0.00%. The fair value of the warrants granted was $38.60 per share. These warrants are recorded in equity at fair value upon issuance, and not as liabilities, and are not subject to adjustment to fair value in subsequent reporting periods. In 2016, we issued 100,000 to the holder of the Debenture. The holder received 50,000 warrants upon the closing on the sale of the Debenture at an exercise price of $30.20, maturing 5 years from issuance, and in accordance with the terms of the amendment agreement, the exercise price of the warrant was reduced to $8.60 per share. The fair value assumptions for the grant included a volatility of 77.13%, expected term of 5.5 years, risk free rate of 1.26%, and a dividend rate of 0.00%. Additionally, the holder received 50,000 warrants upon the Company’s public company announcement of the interim analysis on June 29, 2016 at an exercise price of $8.60. The fair value assumptions for the grant included a volatility of 106.63%, expected term of 5.5 years, risk free rate of 1.35%, and a dividend rate of 0.00%. In addition to the warrants issued to the holder of the debenture we have 15,000 outstanding warrants issued to service providers with a weighted average exercise price of $79.40 as of December 31, 2016 and 2015. These warrants are recorded in equity at fair value upon issuance, and not as liabilities, and are not subject to adjustment to fair value in subsequent reporting periods.

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- Definition The entire disclosure for freestanding option contracts issued by an entity that are indexed to, and potentially settled in, an entity's own stock. Includes disclosure on the strike price and the number of shares to which the contract is indexed, the settlement date or dates of the contract, and the issuer's accounting for the contract. If the terms of the contract provide settlement alternatives, those settlement alternatives are disclosed, including who controls the settlement alternatives, and the maximum number of shares that could be required to be issued, to net share settle the contract, if applicable. If a contract does not have a fixed or determinable maximum number of shares that could be required to be issued, the fact that a potentially infinite number of shares that may be required to be issued to settle the contract is disclosed. Disclosure also includes the contract's current fair value for each settlement alternative and how changes in the price of the issuer's equity instruments affect those settlement amounts. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 40 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6445032&loc=d3e90193-114008 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Freestanding Contract -URI http://asc.fasb.org/extlink&oid=6513800 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 480 -SubTopic 10 -Section 55 -Paragraph 63 -URI http://asc.fasb.org/extlink&oid=6924035&loc=d3e23176-110880 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 40 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6445032&loc=d3e90205-114008 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 40 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=6445032&loc=d3e90198-114008 + Details
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- References No definition available. + Details
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