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Stock-Based Compensation (Tables)

6 Months Ended

12 Months Ended

Jun. 30, 2017

Dec. 31, 2016

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Schedule of Allocated Stock-based Compensation Expense

The following table summarizes the components of stock-based compensation expense in the condensed consolidated statements of operations for the three and six months ended June 30, 2017 and 2016, respectively (in thousands):

		Three Months Ended June 30,								Six Months Ended June 30,
		2017				2016				2017				2016
Research and development		$	35			$	108			$	73			$	235
General and administrative			162				514				352				1,043
Total stock-based compensation from continuing operations		$	197			$	622			$	425			$	1,278

The following table summarizes the components of stock-based compensation expense in the Consolidated Statements of Comprehensive Loss for the years ended December 31, 2016, 2015, and 2014 (in thousands):

		2016				2015				2014
Research and development		$	298			$	350			$	484
General and administrative			1,966				1,591				4,903
Total stock-based compensation		$	2,264			$	1,941			$	5,387

Assumptions for Option Grants Issued

The Company uses the Black-Scholes option-pricing model and the following weighted-average assumptions to determine the fair value of all its stock options granted:

		Three Months Ended June 30,								Six Months Ended June 30,
		2017				2015*				2017				2016
Risk free interest rate			1.58	%			1.41	%			1.87	%			1.41	%
Volatility			132.13	%			76.30	%			116.41	%			75.63	%
Expected lives (years)			5.50				6.25				5.92				6.25
Expected dividend yield			—	%			—	%			—	%			—	%

The Company uses the Black-Scholes option-pricing model and the following weighted-average assumptions to determine the fair value of all its stock options granted:

		2016				2015				2014
Risk free interest rate			1.47	%			1.67	%			2.01	%
Volatility			102.62	%			73.97	%			79.37	%
Expected lives (years)			5.93				6.16				6.16
Expected dividend yield			0.00	%			0.00	%			0.00	%

Stock Option Activity

The following table summarizes stock option activity of the Company for the six months ended June 30, 2017:

		Total Number of Shares (In Thousands)				Weighted Average Exercise Price				Aggregate Intrinsic Value (In Thousands)
Outstanding at January 1, 2017			561			$	41.50
Granted			105				1.30
Exercised			—				—			$	—
Canceled			(161	)			34.21			$	—
Outstanding at June 30, 2017			505			$	35.49			$	—
Options exercisable at June 30, 2017			300			$	54.15			$	—

The following table summarizes option activity of the company:

		Total Number of Shares (In Thousands)				Weighted Average Exercise Price
Outstanding at December 31, 2015			663			$	51.60
Granted			146				9.40
Exercised			(8	)			31.44
Cancelled			(240	)			50.28
Outstanding at December 31, 2016			561			$	41.50
Options exercisable at December 31, 2016			329			$	56.06

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- References

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 14.F)
-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809

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- Definition

Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)
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- Definition

Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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