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    <ACCEPTANCE-DATETIME>20171027194323
    ACCESSION NUMBER:		0001193125-17-323493
    CONFORMED SUBMISSION TYPE:	S-4/A
    PUBLIC DOCUMENT COUNT:		36
    FILED AS OF DATE:		20171030
    DATE AS OF CHANGE:		20171027

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Galena Biopharma, Inc.
    		CENTRAL INDEX KEY:			0001390478
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-4/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-220592
    		FILM NUMBER:		171160526

    	BUSINESS ADDRESS:
    		STREET 1:		4640 SW MACADAM AVENUE
    		STREET 2:		SUITE 270
    		CITY:			PORTLAND
    		STATE:			OR
    		ZIP:			97239
    		BUSINESS PHONE:		855 855 GALE

    	MAIL ADDRESS:
    		STREET 1:		4640 SW MACADAM AVENUE
    		STREET 2:		SUITE 270
    		CITY:			PORTLAND
    		STATE:			OR
    		ZIP:			97239

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RXi Pharmaceuticals Corp
    		DATE OF NAME CHANGE:	20110926

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	GALENA BIOPHARMA, INC.
    		DATE OF NAME CHANGE:	20110922

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RXI PHARMACEUTICALS CORP
    		DATE OF NAME CHANGE:	20110921
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