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Warrants to Acquire Shares of Common Stock - Fair Value of Warrants is Estimated Using Black-Scholes Option Pricing Model (Details) - $ / shares shares in Thousands | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017
Class of Warrant or Right [Line Items] |  |
Warrants outstanding (in shares) | 17,698 | 963
Series A Convertible Preferred |  |
Class of Warrant or Right [Line Items] |  |
Warrants outstanding (in shares) | 1,384 | 0
Strike price (in usd per share) | $ 2.10 |
Expected term (years) | 4 years 9 months 4 days |
Volatility % | 88.80% |
Risk-free rate % | 2.50% |
Galena February 2017 |  |
Class of Warrant or Right [Line Items] |  |
Warrants outstanding (in shares) | 33 | 567
Strike price (in usd per share) | $ 33 | $ 33
Expected term (years) | 3 years 1 month 13 days | 4 years 1 month 13 days
Volatility % | 94.12% | 79.29%
Risk-free rate % | 2.46% | 2.09%
Galena Other |  |
Class of Warrant or Right [Line Items] |  |
Warrants outstanding (in shares) | 72 | 80
Strike price (in usd per share) | $ 829.88 |
Expected term (years) | 2 years 5 months 5 days |
Volatility % | 94.73% |
Risk-free rate % | 2.46% |
Warrants Classified As Liabilities, Other |  |
Class of Warrant or Right [Line Items] |  |
Warrants outstanding (in shares) |  | 76
Strike price (in usd per share) |  | $ 888.22
Expected term (years) |  | 2 years 8 months 26 days
Volatility % |  | 72.46%
Risk-free rate % |  | 2.00%

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- Definition Number of warrants or rights outstanding. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 + Details
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