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Warrants to Acquire Shares of Common Stock (Tables) | 12 Months Ended
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Dec. 31, 2018
Warrants and Rights Note Disclosure [Abstract] |
Schedule Of Warrant Activity Table | The following is a summary of the Company's warrants to acquire shares of common stock activity for the year ended December 31, 2018 (in thousands):
Warrant Issuance | Outstanding, December 31, 2017 |  | Granted |  | Exercised |  | Canceled/Expired |  | Outstanding, December 31, 2018 |  | Expiration
July 2018 Offering | — |  |  | 15,268 |  |  | — |  |  | — |  |  | 15,268 |  |  | July 2023
Pre-funded July 2018 Offering | — |  |  | 4,675 |  |  | (4,050 | ) |  | — |  |  | 625 |  |  | July 2023
Series A Convertible Preferred | — |  |  | 1,384 |  |  | — |  |  |  |  | 1,384 |  |  | September 2023
2017 Equilibria | 316 |  |  | — |  |  | — |  |  |  |  | 316 |  |  | December 2022
Galena February 2017 | 567 |  |  | — |  |  | — |  |  | (534 | ) |  | 33 |  |  | February 2022
Galena Other | 80 |  |  | — |  |  | — |  |  | (8 | ) |  | 72 |  |  | January 2022
| 963 |  |  | 21,327 |  |  | (4,050 | ) |  | (542 | ) |  | 17,698 |  |  |
Fair Value of Warrants is Estimated Using Black-Scholes Option Pricing Model | The fair value of the warrants is estimated using a Black-Scholes pricing model with the following inputs:
As of December 31, 2018
Warrant Issuance | Outstanding (in thousands) |  | Strike price (per share) |  | Expected term (years) |  | Volatility % |  | Risk-free rate %
Series A Convertible Preferred | 1,384 |  |  | $ | 2.10 |  |  | 4.76 |  | 88.80 | % |  | 2.50 | %
Galena February 2017 | 33 |  |  | $ | 33.00 |  |  | 3.12 |  | 94.12 | % |  | 2.46 | %
Galena Other | 72 |  |  | $ | 829.88 |  |  | 2.43 |  | 94.73 | % |  | 2.46 | %
As of December 31, 2017
Warrant Issuance | Outstanding (in thousands) |  | Strike price (per share) |  | Expected term (years) |  | Volatility % |  | Risk-free rate %
Galena February 2017 | 567 |  |  | $ | 33.00 |  |  | 4.12 |  | 79.29 | % |  | 2.09 | %
Galena Other | 76 |  |  | $ | 888.22 |  |  | 2.74 |  | 72.46 | % |  | 2.00 | %
Changes in Fair Value of Warrant Liability | The changes in fair value of the warrant liability for the year ended December 31, 2018 were as follows (in thousands):
Warrant Issuance | Warrant liability, December 31, 2017 |  | Fair value of warrants granted |  | Fair value of warrants canceled |  | Adjustment to exercise price of warrants |  | Change in fair value of warrants |  | Warrant liability, December 31, 2018
Series A Convertible Preferred | $ | — |  |  | $ | 5,039 |  |  | $ | — |  |  | $ | 491 |  |  | $ | (4,520 | ) |  | $ | 1,010 |
Galena February 2017 | 1,305 |  |  | — |  |  | (526 | ) |  | — |  |  | (776 | ) |  | 3 |
Galena Other | 4 |  |  | — |  |  | — |  |  | — |  |  | (4 | ) |  | — |
| $ | 1,309 |  |  | $ | 5,039 |  |  | $ | (526 | ) |  | $ | 491 |  |  | $ | (5,300 | ) |  | $ | 1,013 |

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