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Basis of Presentation and Significant Accounting Policies - Narrative (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Dec. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Jan. 01, 2019
Finite-Lived Intangible Assets [Line Items] |  |  |  |
Impairment loss |  | $ 9,550 | $ 0 |
Intangible assets | $ 8,500 | 8,500 | 17,600 |
Severance costs |  | 0 | 1,883 |
Income tax expense (benefit) |  | (1,378) | 253 |
GALE-401 |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |
Intangible assets | 0 | 0 | 9,100 |
Forecast | Accounting Standards Update 2016-02 | Subsequent Event |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |
Operating lease liability |  |  |  | $ 500
Right-of-use asset |  |  |  | $ 500
IPR&D | GALE-401 |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |
Impairment loss | 9,600 |  |  |
Intangible assets |  |  | $ 9,100 |
Upfront milestone payments, deposits and other assets | $ 500 | $ 500 |  |

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