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Warrants to Acquire Shares of Common Stock (Tables)
 12 Months Ended
Dec. 31, 2018
Warrants and Rights Note Disclosure [Abstract]  
Schedule Of Warrant Activity Table
The following is a summary of the Company's warrants to acquire shares of common stock activity for the year ended December 31, 2018 (in thousands):
 
Warrant Issuance
Outstanding, December 31, 2017
 
Granted
 
Exercised
 
Canceled/Expired
 
Outstanding, December 31, 2018
 
Expiration
July 2018 Offering
—

 
15,268

 
—

 
—

 
15,268

 
July 2023
Pre-funded July 2018 Offering
—

 
4,675

 
(4,050
)
 
—

 
625

 
July 2023
Series A Convertible Preferred
—

 
1,384

 
—

 
 
 
1,384

 
September 2023
2017 Equilibria
316

 
—

 
—

 
 
 
316

 
December 2022
Galena February 2017
567

 
—

 
—

 
(534
)
 
33

 
February 2022
Galena Other
80

 
—

 
—

 
(8
)
 
72

 
January 2022
 
963

 
21,327

 
(4,050
)
 
(542
)
 
17,698

 
 
Fair Value of Warrants is Estimated Using Black-Scholes Option Pricing Model
The fair value of the warrants is estimated using a Black-Scholes pricing model with the following inputs:

As of December 31, 2018
 
 
 
 
 
 
 
 
 
 
Warrant Issuance
Outstanding (in thousands)
 
Strike price (per share)
 
Expected term (years)
 
Volatility %
 
Risk-free rate %
Series A Convertible Preferred
1,384

 
$
2.10

 
4.76
 
88.80
%
 
2.50
%
Galena February 2017
33

 
$
33.00

 
3.12
 
94.12
%
 
2.46
%
Galena Other
72

 
$
829.88

 
2.43
 
94.73
%
 
2.46
%
 
 
 
 
 
 
 
 
 
 
As of December 31, 2017
Warrant Issuance
Outstanding (in thousands)
 
Strike price (per share)
 
Expected term (years)
 
Volatility %
 
Risk-free rate %
Galena February 2017
567

 
$
33.00

 
4.12
 
79.29
%
 
2.09
%
Galena Other
76

 
$
888.22

 
2.74
 
72.46
%
 
2.00
%
Changes in Fair Value of Warrant Liability
The changes in fair value of the warrant liability for the year ended December 31, 2018 were as follows (in thousands):
 
Warrant Issuance
Warrant liability, December 31, 2017
 
Fair value of warrants granted
 
Fair value of warrants canceled
 
Adjustment to exercise price of warrants
 
Change in fair value of warrants
 
Warrant liability, December 31, 2018
Series A Convertible Preferred
$
—

 
$
5,039

 
$
—

 
$
491

 
$
(4,520
)
 
$
1,010

Galena February 2017
1,305

 
—

 
(526
)
 
—

 
(776
)
 
3

Galena Other
4

 
—

 
—

 
—

 
(4
)
 
—

 
$
1,309

 
$
5,039

 
$
(526
)
 
$
491

 
$
(5,300
)
 
$
1,013