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Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2018

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Schedule of Allocated Stock-based Compensation Expense

The following table summarizes the components of stock-based compensation expense in the consolidated statements of operations for the years ended December 31, 2018 and 2017, respectively (in thousands):

	Years Ended December 31,
	2018				2017
Research and development	$	77			$	729
General and administrative	318				2,440
Total stock-based compensation	$	395			$	3,169

Assumptions for Option Grants Issued

The Company uses the Black-Scholes option-pricing model and the following assumptions were used to determine the weighted average fair value of all its stock options granted during the year ended December 31, 2018:

Risk free interest rate	2.73	%
Volatility	80.83	%
Expected lives (years)	6.20
Expected dividend yield	—	%

Stock Option Activity

The following table summarizes stock option activity of the Company for the year ended December 31, 2018:

	Total Number of Shares (In Thousands)			Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value (In Thousands)
Outstanding at January 1, 2018	10			$	1,240.55			1.00		$	—
Granted	483			5.24						—
Canceled	(98	)		5.30						$	—
Outstanding at December 31, 2018	395			$	37.09			9.01		$	—
Options exercisable at December 31, 2018	53			$	241.17			7.63		$	—

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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