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Basis of Presentation and Significant Accounting Policies - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2018	Dec. 31, 2017	Jan. 01, 2019
Finite-Lived Intangible Assets [Line Items]
Impairment loss		$ 9,550	$ 0
Intangible assets	$ 8,500	8,500	17,600
Severance costs		0	1,883
Income tax expense (benefit)		(1,378)	253
GALE-401
Finite-Lived Intangible Assets [Line Items]
Intangible assets	0	0	9,100
Forecast | Accounting Standards Update 2016-02 | Subsequent Event
Finite-Lived Intangible Assets [Line Items]
Operating lease liability				$ 500
Right-of-use asset				$ 500
IPR&D | GALE-401
Finite-Lived Intangible Assets [Line Items]
Impairment loss	9,600
Intangible assets			$ 9,100
Upfront milestone payments, deposits and other assets	$ 500	$ 500

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