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Collaboration and License Agreements - Additional Information (Details) - USD ($)
$ in Thousands
 12 Months Ended
Oct. 11, 2017
May 25, 2017
Feb. 24, 2017
Aug. 10, 2016
Oct. 30, 2015
Sep. 04, 2014
Sep. 11, 2006
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
License And Collaboration Agreements [Line Items]                      
Shares issued under license agreement   8,799       13,199          
Research and development               $ 8,767 $ 6,067    
Memorial Sloan Kettering Cancer Center                      
License And Collaboration Agreements [Line Items]                      
Upfront license fees               300      
Minimum annual royalty payment           $ 100   100 100    
Research funding costs               100 200 $ 200 $ 200
Milestone payments   $ 200       $ 17,400   500 700    
License agreement expiration term           10 years          
Milestone fee payments upon commencement of clinical trials   $ 300                  
License agreement outstanding amount payable               1,000 $ 1,000    
License Agreement Terms | Memorial Sloan Kettering Cancer Center                      
License And Collaboration Agreements [Line Items]                      
Percentage of fully diluted share capital           1.50%          
Upfront license fees           $ 1,300          
Memorial Sloan Kettering Cancer Center Amended And Restated License Agreement                      
License And Collaboration Agreements [Line Items]                      
Shares issued under license agreement   15,399                  
Memorial Sloan Kettering Cancer Center Amended And Restated License Agreement | Memorial Sloan Kettering Cancer Center                      
License And Collaboration Agreements [Line Items]                      
Milestone fee payments upon commencement of clinical trials   $ 400                  
First MSK Amendment | Memorial Sloan Kettering Cancer Center                      
License And Collaboration Agreements [Line Items]                      
Shares issued under license agreement         10,867            
Percentage of fully diluted share capital         1.00%            
Second MSK Amendment | Memorial Sloan Kettering Cancer Center                      
License And Collaboration Agreements [Line Items]                      
Milestone payments $ 700                    
Stock issued during period shares conversion of debt in connection with licensing agreement       13,815              
Additional shares issued in connection with licensing agreement       30,314              
Research and development       $ 2,000              
License agreement outstanding amount payable       $ 900              
Maximum number of days to make payments 60 days                    
Second Amended and Restated Exclusive License Agreement | Memorial Sloan Kettering Cancer Center                      
License And Collaboration Agreements [Line Items]                      
Shares issued under license agreement   74,795                  
Additional shares issued in connection with licensing agreement   7,700                  
Advaxis Collaboration Agreement                      
License And Collaboration Agreements [Line Items]                      
Royalty payment, maximum rate               $ 1,000,000      
Advaxis Collaboration Agreement | Maximum                      
License And Collaboration Agreements [Line Items]                      
Non-refundable milestone payments     $ 108,000                
Non-refundable sales milestone payments     $ 250,000                
The University of Texas M. D. Anderson Cancer Center and The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.                      
License And Collaboration Agreements [Line Items]                      
Milestone payments             $ 3,800        
Annual maintenance fee             $ 200        
Chief Executive Officer Co-Founder | Memorial Sloan Kettering Cancer Center                      
License And Collaboration Agreements [Line Items]                      
Shares issued under license agreement           6,599          
Co-founder | Memorial Sloan Kettering Cancer Center                      
License And Collaboration Agreements [Line Items]                      
Shares issued under license agreement           6,599