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Warrants to Acquire Shares of Common Stock - Schedule of Warrant Activity (Details) shares in Thousands	12 Months Ended
	Dec. 31, 2018 shares
Class of Warrant or Right, Outstanding [Roll Forward]
Warrants outstanding , Beginning balance (in shares)	963
Granted (in shares)	21,327
Exercised (in shares)	(4,050)
Canceled/Expired (in shares)	(542)
Warrants outstanding , Ending balance (in shares)	17,698
July 2018 Offering
Class of Warrant or Right, Outstanding [Roll Forward]
Warrants outstanding , Beginning balance (in shares)	0
Granted (in shares)	15,268
Exercised (in shares)	0
Canceled/Expired (in shares)	0
Warrants outstanding , Ending balance (in shares)	15,268
Pre-funded 2018 Offering
Class of Warrant or Right, Outstanding [Roll Forward]
Warrants outstanding , Beginning balance (in shares)	0
Granted (in shares)	4,675
Exercised (in shares)	(4,050)
Canceled/Expired (in shares)	0
Warrants outstanding , Ending balance (in shares)	625
Series A Convertible Preferred
Class of Warrant or Right, Outstanding [Roll Forward]
Warrants outstanding , Beginning balance (in shares)	0
Granted (in shares)	1,384
Exercised (in shares)	0
Warrants outstanding , Ending balance (in shares)	1,384
2017 Equilibria
Class of Warrant or Right, Outstanding [Roll Forward]
Warrants outstanding , Beginning balance (in shares)	316
Granted (in shares)	0
Exercised (in shares)	0
Warrants outstanding , Ending balance (in shares)	316
Galena February 2017
Class of Warrant or Right, Outstanding [Roll Forward]
Warrants outstanding , Beginning balance (in shares)	567
Granted (in shares)	0
Exercised (in shares)	0
Canceled/Expired (in shares)	(534)
Warrants outstanding , Ending balance (in shares)	33
Galena Other
Class of Warrant or Right, Outstanding [Roll Forward]
Warrants outstanding , Beginning balance (in shares)	80
Granted (in shares)	0
Exercised (in shares)	0
Canceled/Expired (in shares)	(8)
Warrants outstanding , Ending balance (in shares)	72