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Warrants to Acquire Shares of Common Stock - Fair Value of Warrants is Estimated Using Black-Scholes Option Pricing Model (Details) - $ / shares
shares in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Class of Warrant or Right [Line Items]    
Warrants outstanding (in shares) 17,698 963
Series A Convertible Preferred    
Class of Warrant or Right [Line Items]    
Warrants outstanding (in shares) 1,384 0
Strike price (in usd per share) $ 2.10  
Expected term (years) 4 years 9 months 4 days  
Volatility % 88.80%  
Risk-free rate % 2.50%  
Galena February 2017    
Class of Warrant or Right [Line Items]    
Warrants outstanding (in shares) 33 567
Strike price (in usd per share) $ 33 $ 33
Expected term (years) 3 years 1 month 13 days 4 years 1 month 13 days
Volatility % 94.12% 79.29%
Risk-free rate % 2.46% 2.09%
Galena Other    
Class of Warrant or Right [Line Items]    
Warrants outstanding (in shares) 72 80
Strike price (in usd per share) $ 829.88  
Expected term (years) 2 years 5 months 5 days  
Volatility % 94.73%  
Risk-free rate % 2.46%  
Warrants Classified As Liabilities, Other    
Class of Warrant or Right [Line Items]    
Warrants outstanding (in shares)   76
Strike price (in usd per share)   $ 888.22
Expected term (years)   2 years 8 months 26 days
Volatility %   72.46%
Risk-free rate %   2.00%