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Stock-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Allocated Stock-based Compensation Expense
The following table summarizes the components of stock-based compensation expense in the consolidated statements of operations for the years ended December 31, 2021 and 2020, respectively (in thousands):
Years Ended December 31,
20212020
Research and development$126 $14 
General and administrative885 564 
Total stock-based compensation $1,011 $578 
Schedule of Assumptions for Option Grants Issued
The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock-based awards and the following assumptions were used for stock options granted during the years ended December 31, 2021 and 2020, respectively:

Years Ended December 31,
20212020
Risk free interest rate1.05 %0.62 %
Volatility121.53 %106.24 %
Expected lives (years)6.186.15
Expected dividend yield— %— %
Schedule of Stock Option Activity
The following table summarizes stock option activity of the Company for the years ended December 31, 2021 and 2020, respectively:
Total
Number of
Shares (in thousands)
Weighted
Average
Exercise
Price Per Share
Weighted Average Remaining Contractual Term (in years)Aggregate
Intrinsic
Value
(in thousands)
Outstanding at January 1, 202022 $112.81 
Granted186 1.87 
Outstanding at December 31, 2020208 13.38 
Granted326 8.00 
Outstanding at December 31, 2021534 $10.09 8.77$681 
Vested and exercisable at December 31, 2021111 $20.39 8.01$345 
Schedule of RSU Activity
The following table summarizes RSU activity of the Company for the years ended December 31, 2021 and 2020, respectively:

Total Number of Shares
(in thousands)
Weighted Average Grant Date Fair Value Per Share
Unvested at December 31, 2019— $— 
Granted170 $1.89 
Vested— $— 
Unvested at December 31, 2020170 $1.89 
Granted40 $8.00 
Vested(10)$8.00 
Unvested at December 31, 2021200 $2.81