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Liquidity and Going Concern (Details) - USD ($)
3 Months Ended 12 Months Ended
Apr. 16, 2021
Jun. 30, 2022
Dec. 31, 2021
Dec. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Accumulated deficit     $ 138,603,000 $ 117,904,000
Net loss     20,699,000 16,757,000
Cash used in operating activities     26,021,000 10,417,000
Cash and cash equivalents     21,355,000 35,302,000
Proceeds from exercise of warrants     3,069,000 $ 8,535,000
Milestone payment received     2,000,000  
Potential milestone payments to be received     $ 192,500,000  
Forecast        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Milestone payment received   $ 1,000,000    
Sales Agreement        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Sale of stock, authorized amount $ 50,000,000      
Sale of stock, agent fee, percentage of gross proceeds 3.00%      
Number of shares of stock (in shares)     786,927  
Sale of stock, price per share (in dollars per share)     $ 12.04  
Net proceeds of common stock     $ 9,000,000