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Stock-Based Compensation (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Costs and expenses:
Total stock-based compensation expense	$ 1,404	$ 2,052	$ 4,011	$ 5,982
Research and development [Member]
Costs and expenses:
Total stock-based compensation expense	774	975	2,195	2,786
General and administrative [Member]
Costs and expenses:
Total stock-based compensation expense	$ 630	$ 1,077	$ 1,816	$ 3,196

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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