<SEC-DOCUMENT>0001144204-12-061674.txt : 20121113
<SEC-HEADER>0001144204-12-061674.hdr.sgml : 20121112
<ACCEPTANCE-DATETIME>20121113163908
ACCESSION NUMBER:		0001144204-12-061674
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20121113
DATE AS OF CHANGE:		20121113
GROUP MEMBERS:		PETER KOLCHINSKY
GROUP MEMBERS:		RA CAPITAL HEALTHCARE FUND, L.P.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SANGAMO BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001001233
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				680359556
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-59049
		FILM NUMBER:		121199264

	BUSINESS ADDRESS:	
		STREET 1:		501 CANAL BLVD
		STREET 2:		POINT RICHMOND TECH CNTR.
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94804
		BUSINESS PHONE:		5109706000

	MAIL ADDRESS:	
		STREET 1:		501 CANAL BLVD
		STREET 2:		POINT RICHMOND TECH CNTR.
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94804

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RA CAPITAL MANAGEMENT, LLC
		CENTRAL INDEX KEY:			0001346824
		IRS NUMBER:				830406777
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-778-2500

	MAIL ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>v776331_sc13g.htm
<DESCRIPTION>SC 13G
<TEXT>
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<P STYLE="margin: 0">&nbsp;&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SCHEDULE 13G</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Under the Securities Exchange Act of
1934</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>(Amendment No.__)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><BR>
SANGAMO BIOSCIENCES, INC.</P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Common Stock, par value $0.01 </B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B></B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>800677106</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B></B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>October 31, 2012</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B></B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Date of Event Which Requires Filing of
this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box to designate the rule pursuant to
which this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="padding: 0; width: 4%"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD>
    <TD STYLE="padding: 0; width: 92%">Rule 13d-1(b)</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0"><FONT STYLE="font-family: Wingdings">&#120;</FONT></TD>
    <TD STYLE="padding: 0">Rule 13d-1(c)</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD>
    <TD STYLE="padding: 0">Rule 13d-1(d)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*The remainder of this cover page shall be filled out for a
reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The information required in the remainder of this cover page
shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&ldquo;<B><I>Act</I></B>&rdquo;)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<TR>
    <TD STYLE="width: 33%; padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">CUSIP No. <B>800677106</B></TD>
    <TD STYLE="width: 33%; padding: 0; font-size: 12pt; font-weight: bold; text-align: center; border-bottom: Gray 1.5pt solid">13G</TD>
    <TD STYLE="width: 33%; padding: 0; font-size: 10pt; text-align: right; border-bottom: Gray 1.5pt solid">Page <U> <B>2</B> </U> of <U> <B>7</B> </U> Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>























<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">1.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>RA Capital Management, LLC&#9;</B></P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt">2.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt">(a)</TD>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt">(b)</TD>
    <TD COLSPAN="2" STYLE="padding: 0 0 1.5pt; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt">3.</TD>
    <TD COLSPAN="3" STYLE="padding: 0 0 1.5pt; font-size: 10pt">SEC Use Only</TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt">4.</TD>
    <TD COLSPAN="3" STYLE="padding: 0 0 1.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Citizenship or Place of Organization </FONT> <FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Massachusetts</B></FONT></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD COLSPAN="3" ROWSPAN="7" STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">Number of<BR> Shares<BR> Beneficially<BR> Owned by<BR> Each Reporting<BR> Person With</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">5.</TD>
    <TD STYLE="font-size: 10pt; padding: 0; border-bottom: Gray 1.5pt solid">Sole Voting Power <B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2,918,163</B></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">6.</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <B>0</B></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">7.</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">Sole Dispositive Power &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>2,918,163</B></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">8.</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">Shared Dispositive Power <B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0</B></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid; text-align: left; vertical-align: top">9.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting
Person&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>2,918,163</B></P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid; text-align: left; vertical-align: top">10.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes </FONT><FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid; text-align: left; vertical-align: top">11.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>5.5%</B></P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid; text-align: left; vertical-align: top">12.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>IA</B></P></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

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<TR>
    <TD STYLE="border-bottom: Gray 1.5pt solid; padding: 0; font-size: 10pt; width: 33%">CUSIP No. <B>800677106</B></TD>
    <TD STYLE="border-bottom: Gray 1.5pt solid; padding: 0; font-size: 12pt; font-weight: bold; text-align: center; width: 33%">13G</TD>
    <TD STYLE="border-bottom: Gray 1.5pt solid; padding: 0; font-size: 10pt; text-align: right; width: 33%">Page <U> <B>3</B> </U> of <U> <B>7</B> </U> Pages</TD></TR>
</TABLE></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>























<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">1.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; text-indent: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>Peter Kolchinsky&#9;</B></P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt; text-indent: 0">2.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0">Check the Appropriate Box if a Member of a Group (See Instructions)</TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">(a)</TD>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">(b)</TD>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">3.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0">SEC Use Only</TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">4.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><FONT STYLE="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </FONT> <B>United States</B></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD COLSPAN="3" ROWSPAN="7" STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">Number of<BR> Shares<BR> Beneficially<BR> Owned by<BR> Each Reporting<BR> Person With</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">5.</TD>
    <TD STYLE="font-size: 10pt; padding: 0; text-indent: 0; border-bottom: Gray 1.5pt solid">Sole Voting Power <B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2,918,163</B></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">6.</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">Shared Voting Power &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>0</B></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">7.</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">Sole Dispositive Power <B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2,918,163</B></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">8.</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">Shared Dispositive Power <B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0</B></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">9.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; text-indent: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>2,918,163</B></P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">10.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; text-indent: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes </FONT><FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">11.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; text-indent: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>5.5%</B></P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0; border-bottom: Gray 1.5pt solid">12.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; text-indent: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>IN</B></P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>




























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<TR>
    <TD STYLE="border-bottom: Gray 1.5pt solid; padding: 0; font-size: 10pt; width: 33%">CUSIP No. <B>800677106</B></TD>
    <TD STYLE="border-bottom: Gray 1.5pt solid; padding: 0; font-size: 12pt; font-weight: bold; text-align: center; width: 33%">13G</TD>
    <TD STYLE="border-bottom: Gray 1.5pt solid; padding: 0; font-size: 10pt; text-align: right; width: 33%">Page <U> <B>4</B> </U> of <U> <B>7</B> </U> Pages</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;<B>&nbsp;</B></P>























<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">1.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>RA Capital Healthcare Fund, L.P.&#9;</B></P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt">2.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt">(a)</TD>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt">(b)</TD>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt">3.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt">SEC Use Only</TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt">4.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt"><FONT STYLE="font-size: 10pt">Citizenship or Place of Organization &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT> <FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD COLSPAN="3" ROWSPAN="7" STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">Number of<BR> Shares<BR> Beneficially<BR> Owned by<BR> Each Reporting<BR> Person With</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">5.</TD>
    <TD STYLE="font-size: 10pt; padding: 0; border-bottom: Gray 1.5pt solid">Sole Voting Power <B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1,702,011</B></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">6.</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">Shared Voting Power <B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0</B></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">7.</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <B>1,702,011</B></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">8.</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <B>0</B></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">9.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>1,702,011</B></P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">10.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes </FONT><FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">11.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>3.2%</B></P></TD></TR>
<TR>
    <TD COLSPAN="5" STYLE="padding: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; border-bottom: Gray 1.5pt solid">12.</TD>
    <TD COLSPAN="3" STYLE="padding: 0; border-bottom: Gray 1.5pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>PN</B></P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt; width: 33%">CUSIP No. <B>800677106</B></TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 12pt; font-weight: bold; text-align: center; width: 33%"></TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt; text-align: right; width: 33%">Page 5 of 7</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 1.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&#9;<B>Name of Issuer:</B> Sangamo Biosciences, Inc. (the
&ldquo;Issuer&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b)&#9;<B>Address of the Issuer&rsquo;s Principal Executive
Offices:</B> 501 Canal Blvd, Richmond, California 94804.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 2.&#9;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(a)&#9;<B>Name of Person Filing: </B> This
joint statement on Schedule 13G is being filed by Peter Kolchinsky, RA Capital Management, LLC, and RA Capital Healthcare Fund,
L.P., who are collectively referred to herein as the &ldquo;Reporting Persons.&rdquo; Mr. Kolchinsky (the &ldquo;Manager&rdquo;)
is the manager of RA Capital Management, LLC (&ldquo;Capital&rdquo;), which is the investment adviser and sole general partner
of RA Capital Healthcare Fund, L.P. (&ldquo;Fund&rdquo;) and serves as the investment adviser to a separate discretionary account.
The Reporting Persons have entered into a Joint Filing Agreement, dated as of the date hereof, a copy of which is filed with this
Schedule 13G as <U>Exhibit 1</U> (which is incorporated herein by reference), pursuant to which the Reporting Persons have agreed
to file this statement jointly in accordance with the provisions of Rule 13d-1(k) under the Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(b)&#9;<B>Address of Principal Business Office:</B>
The principal business office of the Reporting Persons with respect to the shares reported hereunder is 20 Park Plaza, Suite 1200,
Boston, MA 02116.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(c) &#9;<B>Citizenship:</B> Capital is a Massachusetts
limited liability company. The Fund is a Delaware limited partnership. The Manager is a United States citizen.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(d)&#9;<B>Title and Class of Securities: </B>Common
stock (&ldquo;Common Stock&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(e)&#9;<B>CUSIP Number:</B> 800677106.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3.&#9;If this statement is filed pursuant to &sect;&sect;240.13d-1(b)
or 240.13d-2(b) or (c), check whether the person filing is a:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 4. &#9;Ownership:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">As of the date of this filing the Reporting Persons, in the
aggregate, beneficially own 2,918,163 shares of the Common Stock of the Issuer, representing approximately 5.5% of such class
of securities. The beneficial ownership of each Reporting Person is as follows: (i) Fund beneficially owns 1,702,011 shares of
Common Stock, representing approximately 3.2% of the class and (ii) Capital, as the investment adviser and sole general partner
of the Fund and&nbsp;investment adviser to an account owned by a separate investment vehicle which holds shares of the Issuer's
Common Stock, and<I> </I>Mr. Kolchinsky as the manager of Capital, each beneficially own 2,918,163 shares of Common Stock of the
Issuer, representing approximately 5.5% of the class. The percentage of Common Stock beneficially owned by each Reporting Person
is based on a total of 52,988,561 shares of the Common Stock outstanding as of October 31, 2012 as reported on the Issuer&rsquo;s
Form 10-Q filed on November 02, 2012.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt; width: 33%">CUSIP No. <B>800677106</B></TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 12pt; font-weight: bold; text-align: center; width: 33%"></TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt; text-align: right; width: 33%">Page 6 of 7</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Fund has the power to vote and dispose of the shares of
Common Stock beneficially owned by such entity (as described above). Capital, as the investment adviser and sole general partner
of the Fund and as the investment adviser&nbsp;to&nbsp;an account owned by a separate investment vehicle which holds<FONT STYLE="color: blue"><B><I>
</I></B></FONT>shares of the Issuer&rsquo;s Common Stock, has the sole authority to vote and dispose of all of the shares of Common
Stock reported in this Schedule 13G. The Manager, by virtue of his position as manager of Capital, has the sole authority to vote
and dispose of all of the shares of Common Stock reported in this Schedule 13G.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5.&#9;Ownership of Five Percent or Less of a Class:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in"><B>Item 6.&#9;Ownership of More than
Five Percent on Behalf of Another Person:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 7. &#9;Identification and Classification of the Subsidiary
Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8.&#9;Identification and Classification of Members of
the Group:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 9.&#9;Notice of Dissolution of Group:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 10.&#9;Certification:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">By signing below I hereby certify that, to the best of my knowledge
and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing
or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant
in any transaction having that purpose or effect.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TR>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt; width: 33%">CUSIP No. <B>800677106</B></TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 12pt; font-weight: bold; text-align: center; width: 33%"></TD>
    <TD STYLE="padding: 0 0 1.5pt; font-size: 10pt; text-align: right; width: 33%">Page 7 of 7</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><I>Signature</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">After reasonable inquiry and to the best
of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in"><FONT STYLE="text-transform: uppercase">Date: November
13, 2012</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">RA CAPITAL HEALTHCARE FUND, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">By: RA Capital Management, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in; text-indent: 0.5in">General Partner</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">By: /s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Manager</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in"><BR>
RA CAPITAL MANAGEMENT, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 4in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">By: /s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Manager</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">PETER KOLCHINSKY</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">/s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>Exhibit 1</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>JOINT FILING AGREEMENT</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to Rule 13d-1(k)(1) under the Securities
Exchange Act of 1934, as amended, the undersigned hereby agrees, as of November 13, 2012, that only one statement containing the
information required by Schedule 13G, and each amendment thereto, need be filed with respect to the ownership by each of the undersigned
of shares of Common Stock of Sangamo Biosciences, Inc., and such statement to which this Joint Filing Agreement is attached as
<U>Exhibit 1</U> is filed on behalf of each of the undersigned.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">RA CAPITAL HEALTHCARE FUND, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">By: RA Capital Management, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in; text-indent: 0.5in">General Partner</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">By: /s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Manager</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in"><BR>
RA CAPITAL MANAGEMENT, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">By: /s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Manager</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">PETER KOLCHINSKY</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">/s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">-------------------------------------------------</P>



<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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