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Major Customers, Partnerships and Strategic Alliances (Tables)

12 Months Ended

Dec. 31, 2012

Shire AG [Member]

Research and Development Arrangement, Contract to Perform for Others [Line Items]

Revenues recognized under the agreement

Revenues recognized under the agreement with Shire for the twelve months ended December 31, 2012, were as follows (in thousands):

		Year ended December 31, 2012
Revenues related to Shire Collaboration:
Amortization of upfront fee		$	1,986
Research services			9,026
Total		$	11,012

Sigma-Aldrich Corporation [Member]

Research and Development Arrangement, Contract to Perform for Others [Line Items]

Revenues recognized under the agreement

		Year ended December 31,
		2012				2011				2010
Revenue related to Sigma Collaboration:
Royalty revenues		$	1,288			$	938			$	734
License fee and milestone revenues			1,000				671				11,574
Total			2,288				1,609				12,308

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- Definition

Tabular disclosure of patient service revenue (net of contractual allowances and discounts), by major payor source of revenue for health care organizations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 954

-SubTopic 605

-Section 50

-Paragraph 4

-Subparagraph (b)

-URI http://asc.fasb.org/extlink&oid=9156300&loc=SL9156464-115641



Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 954

-SubTopic 605

-Section 55

-Paragraph 4

-URI http://asc.fasb.org/extlink&oid=9156477&loc=SL9156489-173031

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