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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2012
Income Taxes [Abstract]  
Schedule of company's deferred tax assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

 

                 
    December 31,  
    2012     2011  

Deferred tax assets:

               

Net operating loss carryforwards

  $ 73,129     $ 67,395  

Research and development tax credit carryforwards

    6,770       6,844  

Capitalized research

    5       117  

Stock-based compensation

    7,375       7,355  

Other

    937       1,125  
   

 

 

   

 

 

 
      88,216       82,836  

Valuation allowance

    (88,216     (82,836
   

 

 

   

 

 

 

Net deferred tax assets

  $ —       $ —    
   

 

 

   

 

 

 
Summary of the activity related to the Company's unrecognized tax benefits

The following table summarizes the activity related to the Company’s unrecognized tax benefits (in thousands):

 

                         
    December 31,  
    2012     2011     2010  

Beginning balance

  $ 2,750     $ 1,896     $ 1,643  

Additions based on tax positions related to the current year

    153       589       253  

Additions for tax positions of prior years

    58       265       —    

Reductions for tax positions of prior years

    (227     —         —    
   

 

 

   

 

 

   

 

 

 

Ending balance

  $ 2,734     $ 2,750     $ 1,896