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Stock-Based Compensation (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Costs and expenses:
Total stock-based compensation expense	$ 5,338	$ 8,081	$ 7,818
Research and development [Member]
Costs and expenses:
Total stock-based compensation expense	2,892	3,769	3,612
General and administrative [Member]
Costs and expenses:
Total stock-based compensation expense	$ 2,446	$ 4,312	$ 4,206

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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