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Income Taxes (Details Textual) (USD $)	12 Months Ended
Income Taxes (Details Textual) (USD $)	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Income Taxes (Textual) [Abstract]
Increase in deferred tax asset valuation allowance	$ 5,400,000	$ 19,700,000	$ 7,400,000
Deferred tax assets, net operating loss carryforwards for federal	187,100,000
Deferred tax assets, net operating loss carryforwards for state	163,100,000
Operating loss carryforwards, expiration year	2013
Federal research tax credit carryforwards	6,770,000	6,844,000
State research tax credit carryforwards	5,900,000
Tax credit carryforward, expiration year	2018
Income tax accrued penalties and interest	$ 0

- Definition

Amount before allocation of valuation allowances of deferred tax asset attributable to deductible domestic operating loss carryforwards. Excludes state and local operating loss carryforwards.

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- Definition

Amount before allocation of valuation allowances of deferred tax asset attributable to deductible state and local operating loss carryforwards.

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- Definition

The amount of the change in the period in the valuation allowance for a specified deferred tax asset.

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