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Consolidated Statements of Stockholders' Equity (USD $)
In Thousands, except Share data, unless otherwise specified
Total
Underwritten public offering
Common Stock
Common Stock
Underwritten public offering
Additional Paid-in Capital
Additional Paid-in Capital
Underwritten public offering
Accumulated deficit
Accumulated Other Comprehensive Income/(Loss)
Balances at Dec. 31, 2009 $ 71,782   $ 450   $ 263,955   $ (192,641) $ 18
Balances, shares at Dec. 31, 2009     44,994,409          
Issuance of common stock upon exercise of stock options and in connection with restricted stock units 738   2   736      
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, shares     249,156          
Issuance of common stock under employee stock purchase plan 447   2   445      
Issuance of common stock under employee stock purchase plan, shares     134,174          
Stock-based compensation 7,818       7,818      
Comprehensive loss:                
Net unrealized gain (loss) on marketable securities (24)             (24)
Net loss (24,854)           (24,854)  
Comprehensive loss (24,878)              
Balances at Dec. 31, 2010 55,907   454   272,954   (217,495) (6)
Balances, shares at Dec. 31, 2010     45,377,739          
Issuance of common stock in connection with underwritten public offering   50,219   67   50,152    
Issuance of common stock in connection with underwritten public offering, shares       6,700,000        
Issuance of common stock upon exercise of stock options and in connection with restricted stock units 1,194   3   1,191      
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, shares     324,416          
Issuance of common stock under employee stock purchase plan 463   2   461      
Issuance of common stock under employee stock purchase plan, shares     152,640          
Stock-based compensation 8,081       8,081      
Comprehensive loss:                
Net unrealized gain (loss) on marketable securities 18             18
Net loss (35,750)           (35,750)  
Comprehensive loss (35,732)              
Balances at Dec. 31, 2011 80,132   526   332,839   (253,245) 12
Balances, shares at Dec. 31, 2011     52,554,795          
Issuance of common stock upon exercise of stock options and in connection with restricted stock units 1,219   3   1,216      
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, shares     328,355          
Issuance of common stock under employee stock purchase plan 457   2   455      
Issuance of common stock under employee stock purchase plan, shares     175,375          
Stock-based compensation 5,338       5,338      
Comprehensive loss:                
Net unrealized gain (loss) on marketable securities 14             14
Net loss (22,264)           (22,264)  
Comprehensive loss (22,250)              
Balances at Dec. 31, 2012 $ 64,896   $ 531   $ 339,848   $ (275,509) $ 26
Balances, shares at Dec. 31, 2012     53,058,525