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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 9 Months Ended
Sep. 30, 2013
Sep. 30, 2012
Operating Activities:    
Net loss $ (18,480) $ (18,786)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 445 500
Amortization of premium / discount on marketable securities 625 692
Stock-based compensation 4,098 4,011
Changes in operating assets and liabilities:    
Interest receivable (18) 20
Accounts receivable (696) (2,585)
Prepaid expenses and other assets (387) (364)
Accounts payable and accrued liabilities (1,348) (3,770)
Accrued compensation and employee benefits (434) 159
Deferred revenues (1,630) 11,818
Net cash used in operating activities (17,825) (8,305)
Investing Activities:    
Purchases of investments (37,161) (70,570)
Maturities of investments 38,384 75,155
Purchases of property and equipment (395) (363)
Net cash provided by investing activities 828 4,222
Financing Activities:    
Proceeds from public offering, net of issuance costs 69,492  
Proceeds from issuance of common stock 6,135 1,041
Net cash provided by financing activities 75,627 1,041
Net increase / (decrease) in cash and cash equivalents 58,630 (3,042)
Cash and cash equivalents, beginning of period 21,679 16,766
Cash and cash equivalents, end of period $ 80,309 $ 13,724