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Income Taxes - Additional Information (Detail) (USD $) | 12 Months Ended
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Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Income Taxes [Line Items] |  |  |
Income tax expense | $ 0 |  |
Statutory tax rate | 34.00% |  |
Valuation allowance | 103,107,000 | 88,216,000 |
Increase in deferred tax assets valuation allowance | 14,900,000 | 5,400,000 | 19,700,000
Deferred tax assets, net operating loss carryforwards for federal | 209,000,000 |  |
Deferred tax assets, net operating loss carryforwards for state | 199,000,000 |  |
Operating loss carryforwards, expiration year | 2014 |  |
Federal research tax credit carryforwards | 7,996,000 | 6,770,000 |
State research tax credit carryforwards | 6,500,000 |  |
Tax credit carryforward, expiration year | 2018 |  |
Accrued interest and/or penalties | 0 |  |
Indefinite-lived assets [Member] |  |  |
Income Taxes [Line Items] |  |  |
Valuation allowance | $ 0 |  |

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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible domestic operating loss carryforwards. Excludes state and local operating loss carryforwards. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32621-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32632-109319 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 25 -Paragraph 20 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=29652012&loc=d3e28680-109314 + Details
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