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Major Customers, Partnerships and Strategic Alliances - Agreement with Sigma-Aldrich Corporation - Additional Information (Detail) (USD $) | 12 Months Ended | 1 Months Ended | 12 Months Ended |
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Dec. 31, 2013 | Dec. 31, 2011 | Oct. 31, 2009 Sigma-Aldrich Corporation [Member] | Jul. 31, 2007 Sigma-Aldrich Corporation [Member] | Oct. 31, 2009 Sigma-Aldrich Corporation [Member] Upfront license fee [Member] | Dec. 31, 2013 Sigma-Aldrich Corporation [Member] License agreement terms [Member] | Dec. 31, 2012 Sigma-Aldrich Corporation [Member] License agreement terms [Member] | Dec. 31, 2011 Sigma-Aldrich Corporation [Member] License agreement terms [Member] | Oct. 31, 2009 Sigma-Aldrich Corporation [Member] License agreement terms [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Research program to develop laboratory research reagents |  |  |  | 3 years |  |  |  |  |
Upfront license fee |  |  | $ 20,000,000 |  | $ 15,100,000 |  |  |  |
Common stock, valued | 69,492,000 | 50,219,000 | 4,900,000 |  |  |  |  |  |
Public offering, common stock shares issued |  |  | 636,133 |  |  |  |  |  |
Royalty revenues expected to be received |  |  |  |  |  |  |  |  | 5,000,000
Reduced royalty rate |  |  | 10.50% |  |  |  |  |  |
Funding available under the amended agreement |  |  | 25,000,000 |  |  |  |  |  |
Collaboration agreement related costs and expenses |  |  |  |  |  | $ 200,000 | $ 300,000 | $ 500,000 |

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