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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) (USD $) In Millions, except Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Liquid investments purchased with original maturities | Three months or less |  |
Restricted cash and cash equivalent | $ 0.3 |  |
Intangible assets impairment | 0 |  |
Goodwill impairment | $ 0 |  |
Stock options outstanding | 8,405,864 | 9,184,346 | 8,346,190
Number of operating segments | 1 |  |
Shire AG [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues | 68.00% | 51.00% |
Sigma-Aldrich Corporation [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues | 9.00% | 11.00% | 15.00%
Dow AgroSciences LLC [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues | 12.00% | 22.00% | 43.00%
California Institute for Regenerative Medicine [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues |  |  | 18.00%
CHDI Foundation, Inc. [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues |  |  | 11.00%
U.S [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues | 100.00% | 100.00% | 100.00%
Minimum [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Estimated useful lives of related assets | 3 years |  |
Maximum [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Estimated useful lives of related assets | 5 years |  |

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- Definition For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 21 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=28364263&loc=d3e13537-108611 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 275 -SubTopic 10 -Section 50 -Paragraph 20 -URI http://asc.fasb.org/extlink&oid=6927468&loc=d3e6404-108592 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 20 -URI http://asc.fasb.org/extlink&oid=28364263&loc=d3e13531-108611 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 275 -SubTopic 10 -Section 50 -Paragraph 18 -URI http://asc.fasb.org/extlink&oid=6927468&loc=d3e6351-108592 + Details
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