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v2.4.0.8

Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Operating activities: |  |  |
Net loss | $ (26,624) | $ (22,264) | $ (35,750)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 569 | 660 | 646
Amortization of premium / discount on marketable securities | 912 | 889 | 1,576
Stock-based compensation | 6,146 | 5,338 | 8,081
Net loss on disposal of property and equipment |  | 123 |
Change in fair value of contingent consideration liability | 60 |  |
Net changes in operating assets and liabilities: |  |  |
Restricted cash | (320) |  |
Escrow liability | 275 |  |
Interest receivable | (148) | 141 | 6
Accounts receivable | 1,008 | (3,414) | (553)
Prepaid expenses and other assets | (160) | 14 | (13)
Accounts payable and accrued liabilities | 269 | (1,503) | (139)
Accrued compensation and employee benefits | 721 | 800 | 315
Deferred revenue | (2,190) | 11,134 | (64)
Net cash used in operating activities | (19,482) | (8,082) | (25,895)
Investing activities: |  |  |
Purchases of marketable securities | (118,894) | (91,428) | (112,974)
Maturities of marketable securities | 51,129 | 103,470 | 83,412
Proceeds from sales of marketable securities |  |  | 10,139
Acquistion of Ceregene, Inc., net of cash received | 79 |  |
Purchases of property and equipment | (432) | (723) | (576)
Net cash provided by / (used in) investing activities | (68,118) | 11,319 | (19,999)
Financing activities: |  |  |
Proceeds from public offering of common stock, net of issuance costs | 69,492 |  | 50,152
Taxes paid related to net share settlement of equity awards | (2,015) |  | (48)
Proceeds from issuance of common stock | 8,630 | 1,676 | 1,772
Net cash provided by financing activities | 76,107 | 1,676 | 51,876
Net increase / (decrease) in cash and cash equivalents | (11,493) | 4,913 | 5,982
Cash and cash equivalents, beginning of period | 21,679 | 16,766 | 10,784
Cash and cash equivalents, end of period | 10,186 | 21,679 | 16,766
Supplemental disclosures of noncash investing activities: |  |  |
Fair value of shares of common stock issued pursuant to the acquisition of Ceregene Inc. | $ 1,200 |  |

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Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration