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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) (USD $)
In Millions, except Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Organization and Summary of Significant Accounting Policies [Line Items]      
Liquid investments purchased with original maturities Three months or less    
Restricted cash and cash equivalent $ 0.3    
Intangible assets impairment 0    
Goodwill impairment $ 0    
Stock options outstanding 8,405,864 9,184,346 8,346,190
Number of operating segments 1    
Shire AG [Member]
     
Organization and Summary of Significant Accounting Policies [Line Items]      
Percentage of revenues 68.00% 51.00%  
Sigma-Aldrich Corporation [Member]
     
Organization and Summary of Significant Accounting Policies [Line Items]      
Percentage of revenues 9.00% 11.00% 15.00%
Dow AgroSciences LLC [Member]
     
Organization and Summary of Significant Accounting Policies [Line Items]      
Percentage of revenues 12.00% 22.00% 43.00%
California Institute for Regenerative Medicine [Member]
     
Organization and Summary of Significant Accounting Policies [Line Items]      
Percentage of revenues     18.00%
CHDI Foundation, Inc. [Member]
     
Organization and Summary of Significant Accounting Policies [Line Items]      
Percentage of revenues     11.00%
U.S [Member]
     
Organization and Summary of Significant Accounting Policies [Line Items]      
Percentage of revenues 100.00% 100.00% 100.00%
Minimum [Member]
     
Organization and Summary of Significant Accounting Policies [Line Items]      
Estimated useful lives of related assets 3 years    
Maximum [Member]
     
Organization and Summary of Significant Accounting Policies [Line Items]      
Estimated useful lives of related assets 5 years