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Major Customers, Partnerships and Strategic Alliances - Additional Information (Detail) (USD $)
 1 Months Ended 12 Months Ended
Jun. 30, 2012
Targets
Jan. 31, 2012
Targets
Dec. 31, 2013
Product
Dec. 31, 2012
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Deferred revenue     $ 2,282,000 $ 2,304,000
Shire AG [Member]
        
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Aggregate number of gene targets   7    
Number of initial gene targets   4    
Number of gene targets 5      
Number of additional gene targets 2      
Research program to develop laboratory research reagents     6 years  
Upfront license fee   13,000,000    
Potential amount to be funded for certain Shire milestones     213,500,000  
Potential amount eligible to receive for certain Shire milestones     33,500,000  
Potential amount to be funded for achievement of specified commercialization and sales milestones     180,000,000  
IND or CTA submission amount     8,500,000  
Number of products approved     0  
Royalty revenue     0  
Deferred revenue     8,900,000  
Collaboration agreement related costs and expenses     $ 14,200,000 $ 7,700,000