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Major Customers, Partnerships and Strategic Alliances - Agreement with Sigma-Aldrich Corporation - Additional Information (Detail) (USD $)
 12 Months Ended 1 Months Ended 12 Months Ended
Dec. 31, 2013
Dec. 31, 2011
Oct. 31, 2009
Sigma-Aldrich Corporation [Member]
Jul. 31, 2007
Sigma-Aldrich Corporation [Member]
Oct. 31, 2009
Sigma-Aldrich Corporation [Member]
Upfront license fee [Member]
Dec. 31, 2013
Sigma-Aldrich Corporation [Member]
License agreement terms [Member]
Dec. 31, 2012
Sigma-Aldrich Corporation [Member]
License agreement terms [Member]
Dec. 31, 2011
Sigma-Aldrich Corporation [Member]
License agreement terms [Member]
Oct. 31, 2009
Sigma-Aldrich Corporation [Member]
License agreement terms [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]                  
Research program to develop laboratory research reagents       3 years          
Upfront license fee     $ 20,000,000   $ 15,100,000        
Common stock, valued 69,492,000 50,219,000 4,900,000            
Public offering, common stock shares issued     636,133            
Royalty revenues expected to be received                 5,000,000
Reduced royalty rate     10.50%            
Funding available under the amended agreement     25,000,000            
Collaboration agreement related costs and expenses           $ 200,000 $ 300,000 $ 500,000