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Consolidated Statements of Stockholders' Equity (USD $)
In Thousands, except Share data, unless otherwise specified
Total
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated Deficit [Member]
Accumulated Other Comprehensive Income/ (Loss) [Member]
Beginning Balances at Dec. 31, 2010 $ 55,907 $ 454 $ 272,954 $ (217,495) $ (6)
Beginning Balances, shares at Dec. 31, 2010   45,377,739      
Issuance of common stock in connection with underwritten public offering, net of issuance costs 50,219 67 50,152    
Issuance of common stock in connection with underwritten public offering, net of issuance costs, shares   6,700,000      
Issuance of common stock upon exercise of stock options and in connection with restricted stock units 1,194 3 1,191    
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, shares   324,416      
Issuance of common stock under employee stock purchase plan 463 2 461    
Issuance of common stock under employee stock purchase plan, shares   152,640      
Stock-based compensation 8,081   8,081    
Comprehensive loss:          
Net unrealized gain (loss) on marketable securities 18       18
Net loss (35,750)     (35,750)  
Comprehensive loss (35,732)        
Ending Balances at Dec. 31, 2011 80,132 526 332,839 (253,245) 12
Ending Balances, shares at Dec. 31, 2011   52,554,795      
Issuance of common stock upon exercise of stock options and in connection with restricted stock units 1,219 3 1,216    
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, shares   328,355      
Issuance of common stock under employee stock purchase plan 457 2 455    
Issuance of common stock under employee stock purchase plan, shares   175,375      
Stock-based compensation 5,338   5,338    
Comprehensive loss:          
Net unrealized gain (loss) on marketable securities 14       14
Net loss (22,264)     (22,264)  
Comprehensive loss (22,250)        
Ending Balances at Dec. 31, 2012 64,896 531 339,848 (275,509) 26
Ending Balances, shares at Dec. 31, 2012   53,058,525      
Issuance of common stock in connection with underwritten public offering, net of issuance costs 69,492 70 69,422    
Issuance of common stock in connection with underwritten public offering, net of issuance costs, shares   7,015,000      
Issuance of common stock upon exercise of stock options and in connection with restricted stock units 6,118 19 6,099    
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, shares   1,889,818      
Issuance of common stock under employee stock purchase plan 496 1 495    
Issuance of common stock under employee stock purchase plan, shares   180,551      
Issuance of common stock in connection with acquisition of Ceregene, Inc. 1,200 1 1,199    
Issuance of common stock in connection with acquisition of Ceregene, Inc., shares   99,998      
Stock-based compensation 6,146   6,146    
Comprehensive loss:          
Net unrealized gain (loss) on marketable securities (14)       (14)
Net loss (26,624)     (26,624)  
Comprehensive loss (26,638)        
Ending Balances at Dec. 31, 2013 $ 121,710 $ 622 $ 423,209 $ (302,133) $ 12
Ending Balances, shares at Dec. 31, 2013   62,243,892