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Income Taxes - Additional Information (Detail) (USD $)
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Income Taxes [Line Items]      
Income tax expense $ 0    
Statutory tax rate 34.00%    
Valuation allowance 103,107,000 88,216,000  
Increase in deferred tax assets valuation allowance 14,900,000 5,400,000 19,700,000
Deferred tax assets, net operating loss carryforwards for federal 209,000,000    
Deferred tax assets, net operating loss carryforwards for state 199,000,000    
Operating loss carryforwards, expiration year 2014    
Federal research tax credit carryforwards 7,996,000 6,770,000  
State research tax credit carryforwards 6,500,000    
Tax credit carryforward, expiration year 2018    
Accrued interest and/or penalties 0    
Indefinite-lived assets [Member]
      
Income Taxes [Line Items]      
Valuation allowance $ 0