Major Customers, Partnerships and Strategic Alliances (Tables)

12 Months Ended

Dec. 31, 2014

Revenues recognized under the Biogen Agreement for the twelve months ended December 31, 2014 are as follows (in thousands):

	Year ended
	December 31,
	2014
Revenue related to Biogen Collaboration:
Recognition of upfront fee	$	5,313
Research services		7,751
Total	$	13,064

Revenues recognized under the Shire Agreement for the years ended December 31, 2014, 2013 and 2012, were as follows (in thousands):


	Year ended December 31,
	2014		2013		2012
Revenue related to Shire Collaboration:
Recognition of upfront fee	$	2,167	$	2,167	$	1,986
Recognition of milestone		1,000		—		—
Research services		22,765		14,286		9,026
Total	$	25,932	$	16,453	$	11,012

Revenues recognized under the agreement with Sigma for the years ended December 31, 2014, 2013 and 2012, were as follows (in thousands):


	Year ended December 31,
	2014		2013		2012
Revenue related to Sigma Collaboration:
Royalty revenues	$	344	$	824	$	1,288
License fee and milestone revenues		448		1,351		1,000
Total	$	792	$	2,175	$	2,288