Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	12 Months Ended
Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Operating Activities:
Net loss	$ (26,417)us-gaap_NetIncomeLoss	$ (26,624)us-gaap_NetIncomeLoss	$ (22,264)us-gaap_NetIncomeLoss
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	549	569	660
Amortization of premium on marketable securities	1,098	912	889
Stock-based compensation	9,200us-gaap_ShareBasedCompensation	6,146us-gaap_ShareBasedCompensation	5,338us-gaap_ShareBasedCompensation
Net loss on disposal of property and equipment			123
Change in fair value of contingent consideration liability	230	60
Net changes in operating assets and liabilities:
Restricted cash		(320)
Escrow liability		275
Interest receivable	(85)	(148)	141
Accounts receivable	(7,213)	1,008	(3,414)
Prepaid expenses and other assets	(258)	(160)	14
Accounts payable and accrued liabilities	4,324	269	(1,503)
Accrued compensation and employee benefits	(341)	721	800
Deferred revenues	13,238	(2,190)	11,134
Net cash used in operating activities	(5,675)	(19,482)	(8,082)
Investing Activities:
Purchases of marketable securities	(227,802)	(118,894)	(91,428)
Maturities of marketable securities	127,765	51,129	103,470
Acquistion of Ceregene, Inc., net of cash received		79
Purchases of property and equipment	(621)	(432)	(723)
Net cash provided by / (used in) investing activities	(100,658)	(68,118)	11,319
Financing Activities:
Proceeds from public offering of common stock, net of issuance costs	93,796	69,492
Taxes paid related to net share settlement of equity awards	(4,556)	(2,015)
Proceeds from issuance of common stock	12,937	8,630	1,676
Net cash provided by financing activities	102,177	76,107	1,676
Net increase / (decrease) in cash and cash equivalents	(4,156)	(11,493)	4,913
Cash and cash equivalents, beginning of period	10,186	21,679	16,766
Cash and cash equivalents, end of period	6,030	10,186	21,679
Supplemental disclosure of noncash investing activities:
Fair value of shares of common stock issued pursuant to the acquisition of Ceregene Inc.		$ 1,200

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