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Major Customers, Partnerships and Strategic Alliances - Agreement with Sigma-Aldrich Corporation - Additional Information (Detail) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended
Oct. 31, 2009
Jul. 31, 2007
Sep. 30, 2015
Sep. 30, 2014
Sep. 30, 2015
Sep. 30, 2014
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Research and development     $ 16,694 $ 16,340 $ 47,292 $ 41,883
Sigma-Aldrich Corporation [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Research program to develop laboratory research reagents   3 years        
Upfront license fee $ 20,000          
Public offering, common stock shares issued 636,133          
Amount received on commercial license fees         $ 5,000  
Reduced royalty rate         5.25%  
Funding available under the amended agreement     25,000   $ 25,000  
Sigma-Aldrich Corporation [Member] | Upfront license fee [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Upfront license fee $ 15,100          
Common stock issued under license agreement 4,900          
Sigma-Aldrich Corporation [Member] | License agreement terms [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Royalty revenues expected to be received $ 5,000          
Research and development     $ 0 $ 0 $ 300 $ 100