<SEC-DOCUMENT>0001144204-15-057214.txt : 20150929
<SEC-HEADER>0001144204-15-057214.hdr.sgml : 20150929
<ACCEPTANCE-DATETIME>20150929170859
ACCESSION NUMBER:		0001144204-15-057214
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20150929
DATE AS OF CHANGE:		20150929
GROUP MEMBERS:		PETER KOLCHINSKY
GROUP MEMBERS:		RA CAPITAL HEALTHCARE FUND, L.P.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SANGAMO BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001001233
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				680359556
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-59049
		FILM NUMBER:		151131495

	BUSINESS ADDRESS:	
		STREET 1:		501 CANAL BLVD
		STREET 2:		POINT RICHMOND TECH CNTR.
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94804
		BUSINESS PHONE:		5109706000

	MAIL ADDRESS:	
		STREET 1:		501 CANAL BLVD
		STREET 2:		POINT RICHMOND TECH CNTR.
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94804

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RA CAPITAL MANAGEMENT, LLC
		CENTRAL INDEX KEY:			0001346824
		IRS NUMBER:				830406777
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-778-2500

	MAIL ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>v421278_sc13g-a.htm
<DESCRIPTION>SC 13G/A
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SCHEDULE 13G</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Under the Securities Exchange Act of
1934</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>(Amendment No. 4)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><BR>
SANGAMO BIOSCIENCES, INC.</P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Common Stock, par value $0.01 per share</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B></B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>800677106</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B></B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>September 28, 2015</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Date of Event Which Requires Filing of
this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box to designate the rule pursuant to
which this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
<tr>
    <TD STYLE="padding: 0; text-align: center; width: 5%"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td>
    <TD STYLE="padding: 0; text-indent: 0; width: 95%">Rule 13d-1(b)</td></tr>
<tr>
    <TD STYLE="padding: 0; text-align: center"><FONT STYLE="font-family: Wingdings">&#120;</FONT></td>
    <TD STYLE="padding: 0; text-indent: 0">Rule 13d-1(c)</td></tr>
<tr>
    <TD STYLE="padding: 0; text-align: center"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td>
    <TD STYLE="padding: 0; text-indent: 0">Rule 13d-1(d)</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*The remainder of this cover page shall be filled out for a
reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The information required in the remainder of this cover page
shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&ldquo;<B><I>Act</I></B>&rdquo;)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>




<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">CUSIP No. </font><b>800677106</b></td>
    <TD STYLE="padding: 0; font-size: 12pt; text-align: center; text-indent: 0"><font style="font-size: 12pt"><b>13G</b></font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">



        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0 0 1pt; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding: 0 0 1pt; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">1.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0 0 1pt; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<br>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>RA Capital Management, LLC&#9;</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">2. </font></td>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</font></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">(a)</font></td>
    <TD COLSPAN="4" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">(b)</font></td>
    <TD COLSPAN="4" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">3.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">SEC Use Only </font></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">4.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>&nbsp;<font style="font-size: 10pt"><b>Massachusetts</b></font></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD COLSPAN="3" ROWSPAN="7" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Number of</font><br>
<font style="font-size: 10pt">Shares</font><br>
<font style="font-size: 10pt">Beneficially</font><br>
<font style="font-size: 10pt">Owned by</font><br>
<font style="font-size: 10pt">Each Reporting</font><br>
<font style="font-size: 10pt">Person With</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">5.</font></td>
    <TD COLSPAN="3" STYLE="font-size: 10pt; padding: 0; text-indent: 0"><font style="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="4" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">6.</font></td>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>1,220,209 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="4" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">7.</font></td>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="4" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">8.</font></td>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;<b>1,220,209 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">9.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>1,220,209 shares</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">10.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Check if the Aggregate
Amount in Row (9) Excludes&nbsp;&nbsp; <FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">11.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>1.7%</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">12.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>IA</b></P></td></tr>
<tr>
    <TD STYLE="width: 4%; padding: 0; text-indent: 0; border-bottom: Black 1pt solid">&nbsp;</td>
    <TD STYLE="width: 5%; padding: 0; text-indent: 0; border-bottom: Black 1pt solid">&nbsp;</td>
    <TD STYLE="width: 6%; padding: 0; text-indent: 0; border-bottom: Black 1pt solid">&nbsp;</td>
    <TD STYLE="width: 5%; padding: 0; text-indent: 0; border-bottom: Black 1pt solid">&nbsp;</td>
    <TD STYLE="width: 23%; padding: 0; text-indent: 0; border-bottom: Black 1pt solid">&nbsp;</td>
    <TD STYLE="width: 22%; padding: 0; text-indent: 0; border-bottom: Black 1pt solid">&nbsp;</td>
    <TD STYLE="width: 35%; padding: 0; text-indent: 0; border-bottom: Black 1pt solid">&nbsp;</td></tr>
</table>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">CUSIP No. </font><b>800677106</b></td>
    <TD STYLE="padding: 0; font-size: 12pt; text-align: center; text-indent: 0"><font style="font-size: 12pt"><b>13G</b></font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">



        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">1.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<br>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>Peter Kolchinsky&#9;</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">2. </font></td>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</font></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">(a)</font></td>
    <TD COLSPAN="4" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">(b)</font></td>
    <TD COLSPAN="4" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">3.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">SEC Use Only </font></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">4.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>&nbsp;<b>United States</b></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD COLSPAN="3" ROWSPAN="7" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Number of</font><br>
<font style="font-size: 10pt">Shares</font><br>
<font style="font-size: 10pt">Beneficially</font><br>
<font style="font-size: 10pt">Owned by</font><br>
<font style="font-size: 10pt">Each Reporting</font><br>
<font style="font-size: 10pt">Person With</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">5.</font></td>
    <TD COLSPAN="3" STYLE="font-size: 10pt; padding: 0; text-indent: 0"><font style="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="4" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">6.</font></td>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>1,220,209 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="4" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">7.</font></td>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="4" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">8.</font></td>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>1,220,209 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">9.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>1,220,209 shares</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">10.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Check if the Aggregate
Amount in Row (9) Excludes&nbsp;&nbsp; <FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">11.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>1.7%</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">12.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>IN</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="width: 4%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 5%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 6%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 5%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 23%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 22%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 35%; padding: 0; text-indent: 0">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B></B></P>

<!-- Field: Page; Sequence: 3 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">CUSIP No. </font><b>800677106</b></td>
    <TD STYLE="padding: 0; font-size: 12pt; text-align: center; text-indent: 0"><font style="font-size: 12pt"><b>13G</b></font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">



        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">1.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<br>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>RA Capital Healthcare Fund, L.P.&#9;</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">2. </font></td>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</font></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">(a)</font></td>
    <TD COLSPAN="4" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">(b)</font></td>
    <TD COLSPAN="4" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">3.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">SEC Use Only </font></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">4.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>&nbsp;<font style="font-size: 10pt"><b>Delaware</b></font></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD COLSPAN="3" ROWSPAN="7" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Number of</font><br>
<font style="font-size: 10pt">Shares</font><br>
<font style="font-size: 10pt">Beneficially</font><br>
<font style="font-size: 10pt">Owned by</font><br>
<font style="font-size: 10pt">Each Reporting</font><br>
<font style="font-size: 10pt">Person With</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">5.</font></td>
    <TD COLSPAN="3" STYLE="font-size: 10pt; padding: 0; text-indent: 0"><font style="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="4" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">6.</font></td>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>&nbsp;<font style="font-size: 10pt"><b>872,848 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="4" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">7.</font></td>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="4" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">8.</font></td>
    <TD COLSPAN="3" STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>872,848 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">9.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>872,848 shares</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">10.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes &nbsp;&nbsp;</font><FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">11.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>1.2%</b></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">12.</font></td>
    <TD COLSPAN="5" STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>PN (Limited Partnership)</B></P></td></tr>
<tr>
    <TD COLSPAN="7" STYLE="padding: 0; text-indent: 0; border-bottom: Black 1pt solid">


        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="width: 4%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 5%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 6%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 5%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 23%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 22%; padding: 0; text-indent: 0">&nbsp;</td>
    <TD STYLE="width: 35%; padding: 0; text-indent: 0">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B></B></P>

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    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">CUSIP No. <FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>800677106</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 1.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&#9;<B>Name of Issuer:</B> Sangamo Biosciences, Inc. (the
&ldquo;Issuer&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b)&#9;<B>Address of the Issuer&rsquo;s Principal Executive
Offices:</B> 501 Canal Blvd, Richmond, California 94804.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 2.&#9;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(a)&#9;<B>Name of Person Filing: </B> This
joint statement on Schedule 13G is being filed by Peter Kolchinsky, RA Capital Management, LLC (&ldquo;Capital&rdquo;), and RA
Capital Healthcare Fund, L.P. (the &ldquo;Fund&rdquo;). Mr. Kolchinsky, Capital and the Fund are collectively referred to herein
as the &ldquo;Reporting Persons.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(b)&#9;<B>Address of Principal Business Office:</B>
The principal business office of the Reporting Persons is c/o RA Capital Management, LLC, 20 Park Plaza, Suite 1200, Boston, MA
02116.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(c) &#9;<B>Citizenship:</B> Capital is a Massachusetts
limited liability company. The Fund is a Delaware limited partnership. Mr. Kolchinsky is a United States citizen.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(d)&#9;<B>Title and Class of Securities: </B>Common
stock (&ldquo;Common Stock&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(e)&#9;<B>CUSIP Number:</B> 800677106.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3.&#9;If this statement is filed pursuant to &sect;&sect;240.13d-1(b)
or 240.13d-2(b) or (c), check whether the person filing is a:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 4. &#9;Ownership:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Provide the following information regarding the aggregate number
and percentage of the class of securities of the issuer identified in Item 1.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>(a)</TD>
    <TD>Amount Beneficially Owned:**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC &ndash; 1,220,209
        shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 1,220,209 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P. &ndash;
        872,848 shares</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>(b)</TD>
    <TD>Percent of Class:**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC &ndash; 1.7%</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky &ndash; 1.7%</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P. &ndash;
        1.2%</P></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">CUSIP No. <FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>800677106</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">(c)</td>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt; text-indent: 0">Number of shares as to which such person has:</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="width: 6%; padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="width: 6%; padding: 0; font-size: 10pt; text-indent: 0">(i)</td>
    <TD STYLE="width: 88%; padding: 0; font-size: 10pt; text-indent: 0">sole power to vote or to direct the vote **</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P.
- 0 shares</P></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">(ii)</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">shared power to vote or to direct the vote**</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC &ndash; 1,220,209
        shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 1,220,209 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P.
&ndash; 872,848 shares</P></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">(iii)</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">Sole power to dispose or to direct the disposition of**</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P.
- 0 shares</P></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">(iv)</td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">shared power to dispose or to direct the disposition of**</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="padding: 0; font-size: 10pt; text-indent: 0">&nbsp;</td>
    <TD STYLE="padding: 0; text-indent: 0">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC &ndash; 1,220,209
        shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 1,220,209 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P.
&ndash; 872,848 shares</P></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">**<FONT STYLE="font-size: 10pt">Capital
is the general partner of the Fund and serves as its investment adviser . Capital also serves as investment adviser for a separately
managed account (the &ldquo;Account&rdquo;). As the investment adviser for the Fund and the Account, Capital may be deemed a beneficial
owner, for purposes of Section 13(d) of the Securities Exchange Act of 1934 (the &ldquo;Act&rdquo;), of any securities of the Issuer
owned by the Fund or the Account. Mr. Kolchinsky is the manager of Capital and therefore may be deemed a beneficial owner, for
purposes of Section 13(d) of the Act, of any securities of the Issuer beneficially owned by Capital. Capital is a registered investment
adviser within the meaning of Rule 13d-1(b)(1)(ii)(E), and Mr. Kolchinsky is a control person of Capital within the meaning of
Rule 13d-1(b)(1)(ii)(G). Capital and Mr. Kolchinsky disclaim beneficial ownership of the securities reported above other than for
the purpose of determining their obligations under Section 13(d) of the Act, and the filing of this Amendment shall not be deemed
an admission that either Capital or Mr. Kolchinsky is the beneficial owner of such securities for any other purpose. Shares reported
herein for the Fund represent shares of Common Stock held of record by the Fund. Shares reported herein for Capital represent (a)
the shares of Common Stock reported for the Fund and (b) shares of Common Stock held in the Account.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5.&#9;Ownership of Five Percent or Less of a Class:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If this statement is being filed to report the fact that as
of the date hereof the Reporting Person has ceased to be the beneficial owner of more than five percent of the class of securities,
check the following <FONT STYLE="font-family: Wingdings">&#120;</FONT>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in"><B>Item 6.&#9;Ownership of More than
Five Percent on Behalf of Another Person:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">CUSIP No. <FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>800677106</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 7. &#9;Identification and Classification of the Subsidiary
Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8.&#9;Identification and Classification of Members of
the Group:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 9.&#9;Notice of Dissolution of Group:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 10.&#9;Certification:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">By signing below I hereby certify that, to the best of my knowledge
and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing
or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant
in any transaction having that purpose or effect.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><U>Exhibits</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">1</TD><TD>Joint Filing Agreement by and among the Reporting Persons is incorporated herein by reference to Exhibit 1 to the Schedule
13G filed by the Reporting Persons with the Securities and Exchange Commission on November 13, 2012.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>

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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">After reasonable inquiry and to the best
of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.75in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in"><FONT STYLE="text-transform: uppercase">Date: </FONT>September
29, 2015</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in"><BR>
RA CAPITAL MANAGEMENT, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">By: /s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">Manager</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">PETER KOLCHINSKY</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">/s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">RA CAPITAL HEALTHCARE FUND, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">By: RA Capital Management, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.75in">General Partner</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">By: /s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.25in">Manager</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt"><FONT STYLE="text-transform: uppercase"></FONT></P>

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