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v3.3.1.900

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Operating Activities: |  |  |
Net loss | $ (40,703) | $ (26,417) | $ (26,624)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 988 | 549 | 569
Amortization of premium on marketable securities | 827 | 1,098 | 912
Stock-based compensation | 11,730 | 9,200 | 6,146
Change in fair value of contingent consideration liability | (1,800) | 230 | 60
Intangible impairment | 1,870 |  |
Benefit from income taxes | (5,722) |  |
Net changes in operating assets and liabilities: |  |  |
Interest receivable | 116 | (85) | (148)
Accounts receivable | 7,847 | (7,213) | 1,008
Prepaid expenses and other assets | 376 | (258) | (480)
Accounts payable and accrued liabilities | (764) | 4,324 | 544
Accrued compensation and employee benefits | (105) | (341) | 721
Deferred revenues | (8,380) | 13,238 | (2,190)
Net cash used in operating activities | (33,720) | (5,675) | (19,482)
Investing Activities: |  |  |
Purchases of marketable securities | (257,988) | (227,802) | (118,894)
Maturities of marketable securities | 337,861 | 127,765 | 51,129
Acquisition of Ceregene, Inc., net of cash received |  |  | 79
Purchases of property and equipment | (2,411) | (621) | (432)
Net cash provided by / (used in) investing activities | 77,462 | (100,658) | (68,118)
Financing Activities: |  |  |
Proceeds from public offering of common stock, net of issuance costs |  | 93,796 | 69,492
Taxes paid related to net share settlement of equity awards | (1,546) | (4,556) | (2,015)
Proceeds from issuance of common stock | 6,804 | 12,937 | 8,630
Claims settlement under Section 16(b) | 14,452 |  |
Net cash provided by financing activities | 19,710 | 102,177 | 76,107
Net increase / (decrease) in cash and cash equivalents | 63,452 | (4,156) | (11,493)
Cash and cash equivalents, beginning of period | 6,030 | 10,186 | 21,679
Cash and cash equivalents, end of period | $ 69,482 | $ 6,030 | 10,186
Supplemental disclosure of noncash investing activities: |  |  |
Fair value of shares of common stock issued pursuant to the acquisition of Ceregene Inc. |  |  | $ 1,200

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 + Details
Name: | us-gaap_ShareBasedCompensation
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration