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Major Customers, Partnerships and Strategic Alliances (Tables) | 12 Months Ended
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Dec. 31, 2015
Biogen Inc [Member] |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
Revenues Recognized under Agreement | Revenues recognized under the Biogen Agreement for the years ended December 31, 2015 and 2014 are as follows (in thousands):
|  | Year ended December 31, |
|  | 2015 |  |  | 2014 |
Revenue related to Biogen Collaboration: |  |  |  |  |  |  |  |
Recognition of upfront fee |  | $ | 6,176 |  |  | $ | 5,313 |
Research services |  |  | 7,769 |  |  |  | 7,751 |
Total |  | $ | 13,945 |  |  | $ | 13,064 |
Shire AG [Member] |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
Revenues Recognized under Agreement | Revenues recognized under the Shire Agreement for the years ended December 31, 2015, 2014 and 2013, were as follows (in thousands):
|  | Year ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Revenue related to Shire Collaboration: |  |  |  |  |  |  |  |  |  |  |  |
Recognition of upfront fee |  | $ | 2,167 |  |  | $ | 2,167 |  |  | $ | 2,167 |
Recognition of milestone |  |  | — |  |  |  | 1,000 |  |  |  | — |
Research services |  |  | 13,584 |  |  |  | 22,765 |  |  |  | 14,286 |
Total |  | $ | 15,751 |  |  | $ | 25,932 |  |  | $ | 16,453 |
Sigma-Aldrich Corporation [Member] |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
Revenues Recognized under Agreement | Revenues recognized under the agreement with Sigma for the years ended December 31, 2015, 2014 and 2013, were as follows (in thousands):
|  | Year ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Revenue related to Sigma Collaboration: |  |  |  |  |  |  |  |  |  |  |  |
Royalty revenues |  | $ | 390 |  |  | $ | 344 |  |  | $ | 824 |
License fee and milestone revenues |  |  | 4,463 |  |  |  | 448 |  |  |  | 1,351 |
Total |  | $ | 4,853 |  |  | $ | 792 |  |  | $ | 2,175 |

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- Definition Tabular disclosure of contractual arrangements that involve two or more parties that both: (i) actively participate in a joint operating activity and (ii) are exposed to significant risks and rewards that depend on the commercial success of the joint operating activity. Additionally, the element may include all other transactions of the entity categorized collectively, if such comparison of collaborative arrangements as a component of all transactions of the entity is desired. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 808 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6931272&loc=SL5834143-161434 + Details
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