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Major Customers, Partnerships and Strategic Alliances - California Institute for Regenerative Medicine - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
May. 31, 2014 | May. 31, 2013 | Sep. 30, 2015 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Research grants |  |  |  | $ 1,695 | $ 1,990 | $ 2,455
California Institute for Regenerative Medicine [Member] |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Funds due under the agreement | $ 5,600 |  |  |  |  |
Agreement to receive | 4 years |  |  |  |  |
Research grants |  |  |  | 0 | 0 | 1,200
Collaboration agreement related costs and expenses |  |  |  | 1,700 | 1,800 | 1,800
California Institute for Regenerative Medicine [Member] | Beta-thalassemia [Member] |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Funds due under the agreement |  | $ 6,400 |  |  |  |
Agreement to receive |  | 4 years |  |  |  |
Research grants |  |  |  | 1,200 | 1,400 | 100
Collaboration agreement related costs and expenses |  |  |  | $ 1,200 | $ 1,100 | $ 400
Unused funds received |  |  | $ 3,000 |  |  |

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