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Major Customers, Partnerships and Strategic Alliances - Agreement with Sigma-Aldrich Corporation - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Oct. 31, 2009 | Jul. 31, 2007 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |
Common stock issued under license agreement |  |  |  | $ 93,796 | $ 69,492
Research and development |  |  | $ 67,198 | 56,974 | 37,039
Sigma-Aldrich Corporation [Member] |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |
Research program to develop laboratory research reagents |  | 3 years |  |  |
Upfront license fee | $ 20,000 |  |  |  |
Public offering, common stock shares issued | 636,133 |  |  |  |
Reduced royalty rate | 10.50% |  |  |  |
Funding available under the amended agreement | $ 25,000 |  |  |  |
Sigma-Aldrich Corporation [Member] | Upfront license fee [Member] |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |
Upfront license fee | 15,100 |  |  |  |
Common stock issued under license agreement | 4,900 |  |  |  |
Sigma-Aldrich Corporation [Member] | License agreement terms [Member] |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |
Royalty revenues expected to be received | $ 5,000 |  |  |  |
Research and development |  |  | $ 400 | $ 100 | $ 200

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 + Details
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