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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands | 12 Months Ended
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Dec. 31, 2015 USD ($) Segments shares | Dec. 31, 2014 USD ($) shares | Dec. 31, 2013 USD ($) shares
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Liquid investments purchased with original maturities | three months or less |  |
Restricted cash |  | $ 320 |
Percentage of likelihood of indefinite lived intangible assets being impaired | 50.00% |  |
Impairment charge | $ 1,870 |  |
Change in fair value of contingent liability | $ (1,800) | $ 230 | $ 60
Stock options and restricted stock units outstanding | shares | 9,008,185 | 8,905,782 | 9,469,521
Number of operating segments | Segments | 1 |  |
Shire AG [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues | 40.00% | 57.00% | 68.00%
Biogen Inc [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues | 35.00% | 28.00% |
Sigma-Aldrich Corporation [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues |  |  | 9.00%
Dow AgroSciences LLC [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues |  |  | 12.00%
Minimum [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Estimated useful lives of related assets | 3 years |  |
Maximum [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Estimated useful lives of related assets | 5 years |  |

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