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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Operating Activities:    
Net loss $ (43,069) $ (17,445)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 493 428
Amortization of premium on marketable securities 133 464
Stock-based compensation 10,393 5,836
Change in fair value of contingent consideration liability   (1,800)
Intangible impairment   1,870
Benefit from income taxes (24) (748)
Net changes in operating assets and liabilities:    
Interest receivable 8 30
Accounts receivable 216 5,189
Prepaid expenses and other assets (510) (131)
Accounts payable and accrued liabilities (1,232) 449
Accrued compensation and employee benefits (546) (833)
Deferred revenues (2,399) (3,727)
Net cash used in operating activities (36,537) (10,418)
Investing Activities:    
Purchases of marketable securities (145,890) (120,895)
Maturities of marketable securities 126,087 133,235
Purchases of property and equipment (356) (2,082)
Net cash provided by / (used in) investing activities (20,159) 10,258
Financing Activities:    
Taxes paid related to net share settlement of equity awards (534) (48)
Proceeds from issuance of common stock 703 4,946
Net cash provided by financing activities 169 4,898
Net increase / (decrease) in cash and cash equivalents (56,527) 4,738
Cash and cash equivalents, beginning of period 69,482 6,030
Cash and cash equivalents, end of period 12,955 10,768
Supplemental disclosure of noncash investing activities:    
Property and equipment included in accrued liabilities $ 247 $ 84