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v3.6.0.2

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating Activities: |  |  |
Net loss | $ (71,658) | $ (40,703) | $ (26,417)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 997 | 988 | 549
Amortization of premium on marketable securities | 221 | 827 | 1,098
Stock-based compensation | 15,057 | 11,730 | 9,200
Change in fair value of contingent consideration liability |  | (1,800) | 230
Intangible impairment |  | 1,870 |
Benefit from income taxes | (14) | (5,722) |
Other | 99 |  |
Net changes in operating assets and liabilities: |  |  |
Interest receivable | 83 | 116 | (85)
Accounts receivable | (2,144) | 7,847 | (7,213)
Prepaid expenses and other assets | (1,112) | 376 | (258)
Accounts payable and accrued liabilities | (2,335) | (764) | 4,324
Accrued compensation and employee benefits | 137 | (105) | (341)
Deferred revenues | (5,214) | (8,380) | 13,238
Net cash used in operating activities | (65,883) | (33,720) | (5,675)
Investing Activities: |  |  |
Purchases of marketable securities | (218,640) | (257,988) | (227,802)
Maturities of marketable securities | 237,497 | 337,861 | 127,765
Purchase of property and equipment | (732) |  |
Acquisition of Ceregene, Inc., net of cash received |  | (2,411) | (621)
Net cash provided by / (used in) investing activities | 18,125 | 77,462 | (100,658)
Financing Activities: |  |  |
Proceeds from public offering of common stock, net of issuance costs |  |  | 93,796
Taxes paid related to net share settlement of equity awards | (776) | (1,546) | (4,556)
Proceeds from issuance of common stock | 1,113 | 6,804 | 12,937
Claims settlement under Section 16(b) |  | 14,452 |
Net cash provided by financing activities | 337 | 19,710 | 102,177
Net increase / (decrease) in cash and cash equivalents | (47,421) | 63,452 | (4,156)
Cash and cash equivalents, beginning of period | 69,482 | 6,030 | 10,186
Cash and cash equivalents, end of period | 22,061 | $ 69,482 | $ 6,030
Supplemental disclosure of noncash investing activities: |  |  |
Build-to-suit lease in accrued liabilities | $ 3,876 |  |

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- Definition The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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