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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ / shares in Units, $ in Thousands | 12 Months Ended
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Dec. 31, 2016 USD ($) Segments $ / shares shares | Dec. 31, 2015 USD ($) shares | Dec. 31, 2014 USD ($) shares
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Liquid investments purchased with original maturities | three months or less |  |
Restricted cash |  |  | $ 300
Percentage of likelihood of indefinite lived intangible assets being impaired | 50.00% |  |
Impairment charge |  | $ 1,870 |
Change in fair value of contingent liability |  | $ (1,800) | $ 230
Stock options and restricted stock units outstanding | shares | 9,578,322 | 9,008,185 | 8,905,782
Number of operating segments | Segments | 1 |  |
Bioverativ Inc [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues | 46.00% |  |
Bioverativ Inc [Member] | Change in estimated performance period [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Increase in net loss | $ 4,300 |  |
Increase in basic net loss per share | $ / shares | $ 0.06 |  |
Decrease in revenues | $ 4,300 |  |
Dow Agro Sciences [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues | 26.00% |  |
Shire AG [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues | 17.00% | 40.00% | 57.00%
Biogen Inc [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Percentage of revenues |  | 35.00% | 28.00%
Minimum [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Estimated useful lives of related assets | 3 years |  |
Maximum [Member] |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Estimated useful lives of related assets | 5 years |  |

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