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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2016
Income Tax Disclosure [Abstract] |
Summary of Benefit for Income Taxes | The benefit for income taxes consisted of the following (in thousands):
|  | 2016 |  |  | 2015 |  |  | 2014 |
Benefit for income taxes: |  |  |  |  |  |  |  |  |  |  |  |
Current: |  |  |  |  |  |  |  |  |  |  |  |
Federal |  | $ | — |  |  | $ | — |  |  | $ | — |
State |  |  | — |  |  |  | — |  |  |  | — |
Subtotal |  |  | — |  |  |  | — |  |  |  | — |
Deferred: |  |  |  |  |  |  |  |  |  |  |  |
Federal |  | $ | (12 | ) |  | $ | (5,563 | ) |  | $ | — |
State |  |  | (2 | ) |  |  | (159 | ) |  |  | — |
Subtotal |  |  | (14 | ) |  |  | (5,722 | ) |  |  | — |
Income tax benefit |  | $ | (14 | ) |  | $ | (5,722 | ) |  | $ | — |
Schedule of Difference Between Benefit for Income Taxes and Federal Statutory Income Tax Rate | The difference between the benefit for income taxes and the amount computed by applying the federal statutory income tax rate (34%) to loss before taxes is explained as follows (in thousands):
|  | Year ended December 31, |
|  | 2016 |  |  | 2015 |  |  | 2014 |
Tax at federal statutory rate |  | $ | (24,369 | ) |  | $ | (15,785 | ) |  | $ | (8,982 | )
State taxes, net |  |  | (747 | ) |  |  | 4,840 |  |  |  | (822 | )
Non-deductible stock compensation |  |  | 2,781 |  |  |  | 1,085 |  |  |  | (148 | )
Research credits |  |  | (1,424 | ) |  |  | (814 | ) |  |  | (320 | )
Change in valuation allowance |  |  | 23,773 |  |  |  | 5,043 |  |  |  | 9,778 |
Other |  |  | (28 | ) |  |  | (91 | ) |  |  | 494 |
Income tax benefit |  | $ | (14 | ) |  | $ | (5,722 | ) |  | $ | — |
Schedule of Company's Deferred Tax Assets | Significant components of the Company’s deferred tax assets are as follows (in thousands):
|  | December 31, |
|  | 2016 |  |  | 2015 |
Assets: |  |  |  |  |  |  |  |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 114,222 |  |  | $ | 93,824 |
Research and development tax credit carryforwards |  |  | 12,518 |  |  |  | 9,979 |
Stock-based compensation |  |  | 8,565 |  |  |  | 6,853 |
Deferred revenue |  |  | 2,918 |  |  |  | 4,479 |
Other |  |  | 3,492 |  |  |  | 2,807 |
Total deferred tax asset |  |  | 141,715 |  |  |  | 117,942 |
Valuation allowance |  |  | 141,715 |  |  |  | 117,942 |
Net deferred tax assets |  | $ | — |  |  | $ | — |
Liabilities: |  |  |  |  |  |  |  |
Net deferred tax liability related to intangible assets |  |  | — |  |  |  | — |
Total deferred tax liability |  | $ | — |  |  | $ | — |
Summary of Activity Related to Company's Unrecognized Tax Benefits | The following table summarizes the activity related to the Company’s unrecognized tax benefits (in thousands):
|  | December 31, |
|  | 2016 |  |  | 2015 |  |  | 2014 |
Beginning balance |  | $ | 8,330 |  |  | $ | 3,438 |  |  | $ | 3,182 |
Additions based on tax positions related to the current year |  |  | 1,023 |  |  |  | 557 |  |  |  | 228 |
Additions for tax positions of prior years |  |  | 27 |  |  |  | 4,335 |  |  |  | 28 |
Reductions for tax positions of prior years |  |  | (4,335 | ) |  |  | — |  |  |  | — |
Ending balance |  | $ | 5,045 |  |  | $ | 8,330 |  |  | $ | 3,438 |

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- Definition Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32639-109319 + Details
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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32687-109319 + Details
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- Definition Tabular disclosure of unrecognized tax benefits for which a material change is reasonably possible in the next twelve months, typically including the nature of the uncertainty, the event(s) that could cause a material change, and an estimate of the range of the reasonably possible change or a statement that an estimate of the range cannot be made. An unrecognized tax benefit is the difference between a tax position taken in a tax return and the amounts recognized in the financial statements for which it is more likely than not, based on the technical merits of the position, that the tax position will not be sustained upon examination. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 15 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32718-109319 + Details
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