Major Customers, Partnerships and Strategic Alliances (Tables)

12 Months Ended

Dec. 31, 2016

Revenues recognized under the Bioverativ Agreement for the years ended December 31, 2016, 2015 and 2014 are as follows (in thousands):


	Year ended December 31,
	2016		2015		2014
Revenue related to Bioverativ Collaboration:
Recognition of upfront fee	$	2,321	$	6,176	$	5,313
Research services		6,565		7,769		7,751
Total	$	8,886	$	13,945	$	13,064

Revenues recognized under the Shire Agreement for the years ended December 31, 2016, 2015 and 2014, were as follows (in thousands):


	Year ended December 31,
	2016		2015		2014
Revenue related to Shire Collaboration:
Recognition of upfront fee	$	2,181	$	2,167	$	2,167
Recognition of milestone		—		—		1,000
Research services		1,096		13,584		22,765
Total	$	3,277	$	15,751	$	25,932

Revenues recognized under the agreement with Sigma for the years ended December 31, 2016, 2015 and 2014, were as follows (in thousands):


	Year ended December 31,
	2016		2015		2014
Revenue related to Sigma Collaboration:
Royalty revenues	$	137	$	390	$	344
License fee and milestone revenues		1,140		4,463		448
Total	$	1,277	$	4,853	$	792