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Major Customers, Partnerships and Strategic Alliances - Agreement with Sigma-Aldrich Corporation - Additional Information (Detail) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended
Oct. 31, 2009
Jul. 31, 2007
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Research and development     $ 18,425 $ 17,008 $ 46,351 $ 51,728
Sigma-Aldrich Corporation [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Research program to develop laboratory research reagents   3 years        
Upfront license fee $ 20,000          
Public offering, common stock shares issued 636,133          
Reduced royalty rate 10.50%          
Funding available under the amended agreement $ 25,000          
Sigma-Aldrich Corporation [Member] | Upfront license fee [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Upfront license fee 15,100          
Common stock issued under license agreement $ 4,900          
Sigma-Aldrich Corporation [Member] | License agreement terms [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Revenues under agreement         5,000  
Research and development     $ 0 $ 0 $ 0 $ 0