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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Summary of Benefit for Income Taxes

The benefit for income taxes consisted of the following (in thousands):  

		Year Ended December 31,
		2017				2016				2015
Benefit for income taxes:
Current:
Federal		$	—			$	—			$	—
State			—				—				—
Subtotal			—				—				—
Deferred:
Federal		$	—			$	(12	)		$	(5,563	)
State			—				(2	)			(159	)
Subtotal			—				(14	)			(5,722	)
Income tax benefit		$	—			$	(14	)		$	(5,722	)

Schedule of Difference Between Benefit for Income Taxes and Federal Statutory Income Tax Rate

The difference between the benefit for income taxes and the amount computed by applying the federal statutory income tax rate (34%) to loss before taxes is explained as follows (in thousands):

		Year Ended December 31,
		2017				2016				2015
Tax at federal statutory rate		$	(18,553	)		$	(24,369	)		$	(15,785	)
State taxes, net			795				(747	)			4,840
Federal Rate Change			53,045				—				—
Non-deductible stock compensation			2,120				2,781				1,085
Research credits			(869	)			(1,424	)			(814	)
Change in valuation allowance			(36,575	)			23,773				5,043
Other			37				(28	)			(91	)
Income tax benefit		$	—			$	(14	)		$	(5,722	)

Schedule of Company's Deferred Tax Assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

		December 31 ,
		2017				2016
Assets:
Deferred tax assets:
Net operating loss carryforwards		$	91,308			$	114,222
Research and development tax credit carryforwards			15,147				12,518
Stock-based compensation			3,168				8,565
Deferred revenue			934				2,918
Other			2,276				3,492
Total deferred tax asset			112,833				141,715
Valuation allowance			112,833				141,715
Net deferred tax assets		$	—			$	—
Liabilities:
Net deferred tax liability related to intangible assets			—				—
Total deferred tax liability		$	—			$	—

Summary of Activity Related to Company's Unrecognized Tax Benefits

The following table summarizes the activity related to the Company’s unrecognized tax benefits (in thousands):

		December 31,
		2017				2016				2015
Beginning balance		$	5,045			$	8,330			$	3,438
Additions based on tax positions related to the current year			622				1,023				557
Additions for tax positions of prior years			(8	)			27				4,335
Reductions for tax positions of prior years			—				(4,335	)			—
Ending balance		$	5,659			$	5,045			$	8,330

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- References

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- Definition

Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319

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Tabular disclosure of unrecognized tax benefits for which a material change is reasonably possible in the next twelve months, typically including the nature of the uncertainty, the event(s) that could cause a material change, and an estimate of the range of the reasonably possible change or a statement that an estimate of the range cannot be made. An unrecognized tax benefit is the difference between a tax position taken in a tax return and the amounts recognized in the financial statements for which it is more likely than not, based on the technical merits of the position, that the tax position will not be sustained upon examination.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 15
-Subparagraph (d)
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32718-109319

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