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Major Customers, Partnerships and Strategic Alliances - Agreement with Sigma-Aldrich Corporation - Additional Information (Detail) - USD ($)
$ in Thousands
 1 Months Ended 12 Months Ended
Oct. 31, 2009
Dec. 31, 2017
Dec. 31, 2007
Research and Development Arrangement, Contract to Perform for Others [Line Items]      
Common stock issued under license agreement   $ 81,573  
Sigma-Aldrich Corporation [Member]      
Research and Development Arrangement, Contract to Perform for Others [Line Items]      
Developed laboratory research reagents, research services period     3 years
Upfront license fee $ 20,000    
Public offering, common stock shares issued 636,133    
Reduced royalty rate 10.50%    
Funding available under the amended agreement $ 25,000    
Sigma-Aldrich Corporation [Member] | Upfront license fee [Member]      
Research and Development Arrangement, Contract to Perform for Others [Line Items]      
Upfront license fee 15,100    
Common stock issued under license agreement $ 4,900    
Sigma-Aldrich Corporation [Member] | License agreement terms [Member]      
Research and Development Arrangement, Contract to Perform for Others [Line Items]      
Revenues under agreement   $ 5,000