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Commitments and Contingencies - Additional Information (Detail)
$ in Millions
 1 Months Ended 12 Months Ended
Nov. 30, 2017
ft²
Dec. 31, 2017
USD ($)
ft²
Property
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Commitments And Contingencies [Line Items]        
Additional property available under lease | Property   3    
Number of built-to-suit lease properties | Property   2    
Rent expenses | $   $ 1.1 $ 1.0 $ 0.9
Intellectual Property [Member]        
Commitments And Contingencies [Line Items]        
License commitments | $   $ 5.2    
Richmond Build-to-Suit Lease [Member]        
Commitments And Contingencies [Line Items]        
Lease expiration date   Dec. 31, 2021    
Property leased | ft²   41,400    
Brisbane Build-to-Suit Lease [Member]        
Commitments And Contingencies [Line Items]        
Lease expiration date   May 31, 2029    
Property leased | ft² 87,700 87,700    
Brisbane Build-to-Suit Lease [Member] | Tenant Improvements [Member]        
Commitments And Contingencies [Line Items]        
Other commitments for next twelve months | $   $ 8.8    
Services Agreement to Provide Dedicated Capacity to Supply Preclinical and Clinical Programs [Member] | Tenant Improvements [Member]        
Commitments And Contingencies [Line Items]        
Other commitments for next twelve months | $   $ 8.7    
Operating Lease One [Member] | Research and Office Space [Member]        
Commitments And Contingencies [Line Items]        
Area of space leased | ft²   7,700    
Lease expiration date   Aug. 31, 2019    
Operating Lease Two [Member]        
Commitments And Contingencies [Line Items]        
Area of space leased | ft²   6,200    
Lease expiration date   Jul. 31, 2021