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Income Taxes - Schedule of Difference Between Benefit for Income Taxes and Federal Statutory Income Tax Rate (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Tax Disclosure [Abstract]
Tax at federal statutory rate	$ (18,553)	$ (24,369)	$ (15,785)
State taxes, net	795	(747)	4,840
Federal Rate Change	53,045
Non-deductible stock compensation	2,120	2,781	1,085
Research credits	(869)	(1,424)	(814)
Change in valuation allowance	(36,575)	23,773	5,043
Other	$ 37	(28)	(91)
Income tax benefit		$ (14)	$ (5,722)

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.

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