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Organization, Basis of Presentation and Summary of Significant Accounting Policies - Condensed Consolidated Statement of Operations and Comprehensive Loss (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenue Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenue	$ 12,551	$ 3,306
Net loss	$ (20,187)	$ (16,632)
Basic and diluted net loss per share	$ (0.23)	$ (0.23)
Adjustments [Member] | Topic 606 [Member]
Revenue Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenue	$ 1,746
Net loss	$ 1,746
Basic and diluted net loss per share	$ 0.02
Balances without adoption of Topic 606 [Member] | Topic 606 [Member]
Revenue Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenue	$ 10,805
Net loss	$ (21,933)
Basic and diluted net loss per share	$ (0.25)

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-SubTopic 10
-Section 45
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