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Organization, Basis of Presentation and Summary of Significant Accounting Policies - Condensed Consolidated Statement of Operations and Comprehensive Loss (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017
Revenue Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |
Revenue | $ 21,416 | $ 8,253 | $ 34,053 | $ 11,678
Net loss | $ (16,640) | $ (12,491) | $ (36,827) | $ (29,123)
Basic and diluted net loss per share | $ (0.17) | $ (0.17) | $ (0.40) | $ (0.41)
Collaboration Agreements [Member] |  |  |  |
Revenue Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |
Revenue | $ 21,289 | $ 7,977 | $ 33,840 | $ 11,283
Adjustments [Member] | Topic 606 [Member] |  |  |  |
Revenue Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |
Net loss | $ (2,271) |  | $ (4,047) |
Basic and diluted net loss per share | $ (0.02) |  | $ (0.04) |
Adjustments [Member] | Collaboration Agreements [Member] | Topic 606 [Member] |  |  |  |
Revenue Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |
Revenue | $ (2,271) |  | $ (4,047) |
Balances without adoption of Topic 606 [Member] | Topic 606 [Member] |  |  |  |
Revenue Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |
Net loss | $ (18,911) |  | $ (40,874) |
Basic and diluted net loss per share | $ (0.19) |  | $ (0.44) |
Balances without adoption of Topic 606 [Member] | Collaboration Agreements [Member] | Topic 606 [Member] |  |  |  |
Revenue Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |
Revenue | $ 19,018 |  | $ 29,793 |

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- Definition The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 45 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=109260490&loc=d3e1337-109256 + Details
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