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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ / shares in Units, $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2018 USD ($) Segments shares | Dec. 31, 2017 USD ($) shares | Dec. 31, 2016 USD ($) $ / shares shares | Jan. 01, 2018 USD ($)
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Liquid investments purchased with original maturities | three months or less |  |  |
Percentage of likelihood of indefinite lived intangible assets being impaired | 50.00% |  |  |
Percentage of likelihood of income tax examination favourable settlement being realized | 50.00% |  |  |
Stock options and RSUs outstanding | shares | 9,048,793 | 8,367,628 | 9,578,322 |
Number of operating segments | Segments | 1 |  |  |
Accumulated deficit | $ (562,696) | $ (495,479) |  |
Restricted cash | 3,500 | $ 3,500 |  |
Brisbane Build-to-Suit Lease [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Restricted cash | 3,500 |  |  |
ASU No. 2014-09 [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Accumulated deficit |  |  |  | $ (494,362)
ASU No. 2014-09 [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Accumulated deficit | $ (14,674) |  |  | 1,117
ASU 2016-18 [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Restricted cash balance |  |  |  | $ 3,500
Bioverativ Inc [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Percentage of revenues |  | 34.00% | 46.00% |
Bioverativ Inc [Member] | Collaboration Contract Performance Period |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Increase in basic net loss per share | $ / shares |  |  | $ 0.06 |
Decrease in revenues |  |  | $ 4,300 |
Pfizer [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Percentage of revenues | 45.00% | 47.00% |  |
Kite Pharma, Inc. ("Kite") [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Percentage of revenues | 30.00% |  |  |
Dow Agro Sciences [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Percentage of revenues |  |  | 26.00% |
Shire AG [Member] | Customer Concentration Risk [Member] | Total revenues [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Percentage of revenues |  |  | 17.00% |
Minimum [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Estimated useful lives of related assets | 3 years |  |  |
Maximum [Member] |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |
Estimated useful lives of related assets | 5 years |  |  |

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