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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Common Stock [Member] | Additional Paid-in Capital [Member] | Accumulated Deficit [Member] | Accumulated Other Comprehensive Income/ (Loss) [Member] | Non-Controlling Interest [Member]
--- | --- | --- | --- | --- | --- | ---
Beginning Balances at Dec. 31, 2015 | $ 192,439 | $ 703 | $ 560,989 | $ (369,253) |  |
Beginning Balances, shares at Dec. 31, 2015 |  | 70,354,608 |  |  |  |
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax | (481) | $ 3 | (484) |  |  |
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax, shares |  | 314,583 |  |  |  |
Issuance of common stock under employee stock purchase plan | $ 818 | $ 3 | 815 |  |  |
Issuance of common stock under employee stock purchase plan, shares | 202,711 | 202,711 |  |  |  |
Stock-based compensation | $ 15,057 |  | 15,057 |  |  |
Comprehensive loss: |  |  |  |  |  |
Net unrealized gain (loss) on marketable securities, net of tax | 20 |  |  |  | $ 20 |
Net loss | (71,658) |  |  | (71,658) |  |
Comprehensive loss | (71,638) |  |  |  |  |
Ending Balances at Dec. 31, 2016 | 136,195 | $ 709 | 576,377 | (440,911) | 20 |
Ending Balances, shares at Dec. 31, 2016 |  | 70,871,902 |  |  |  |
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax | 15,099 | $ 21 | 15,078 |  |  |
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax, shares |  | 2,101,489 |  |  |  |
Issuance of common stock under employee stock purchase plan | $ 818 | $ 2 | 816 |  |  |
Issuance of common stock under employee stock purchase plan, shares | 253,994 | 253,994 |  |  |  |
Issuance of common stock under public offering, net of issuance costs | $ 81,573 | $ 124 | 81,449 |  |  |
Issuance of common stock under public offering, net of issuance costs, shares |  | 12,371,149 |  |  |  |
Stock-based compensation | 9,089 |  | 9,089 |  |  |
Comprehensive loss: |  |  |  |  |  |
Net unrealized gain (loss) on marketable securities, net of tax | (306) |  |  |  | (306) |
Net loss | (54,568) |  |  | (54,568) |  |
Comprehensive loss | (54,874) |  |  |  |  |
Ending Balances at Dec. 31, 2017 | $ 187,900 | $ 856 | 682,809 | (495,479) | (286) |
Ending Balances, shares at Dec. 31, 2017 | 85,598,534 | 85,598,534 |  |  |  |
Cumulative-effect adjustment of ASC Topic606 on January 1, 2018 | $ 1,117 |  |  | 1,117 |  |
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax | 14,467 | $ 20 | 14,447 |  |  |
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax, shares |  | 2,103,727 |  |  |  |
Issuance of common stock under employee stock purchase plan | $ 1,484 | $ 4 | 1,480 |  |  |
Issuance of common stock under employee stock purchase plan, shares | 328,710 | 328,710 |  |  |  |
Issuance of common stock under public offering, net of issuance costs | $ 215,758 | $ 142 | 215,616 |  |  |
Issuance of common stock under public offering, net of issuance costs, shares |  | 14,156,500 |  |  |  |
Stock-based compensation | 14,677 |  | 14,677 |  |  |
Additional Paid in Capital for Acquisition of TxCell | 603 |  | 603 |  |  |
Non-Controlling Interest upon Acquisition of TxCell | 1,313 |  |  |  |  | $ 1,313
Comprehensive loss: |  |  |  |  |  |
Foreign currency translation adjustment | (1,148) |  |  |  | (1,129) | (19)
Net pension losses | (21) |  |  |  | (21) |
Net unrealized gain (loss) on marketable securities, net of tax | (4) |  |  |  | (4) |
Net loss | (68,889) |  |  | (68,334) |  | (555)
Comprehensive loss | (70,062) |  |  |  |  |
Ending Balances at Dec. 31, 2018 | $ 367,257 | $ 1,022 | $ 929,632 | $ (562,696) | $ (1,440) | $ 739
Ending Balances, shares at Dec. 31, 2018 | 102,187,471 | 102,187,471 |  |  |  |

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- Definition Amount of stockholders' equity (deficit), net of receivables from officers, directors, owners, and affiliates of the entity, attributable to both the parent and noncontrolling interests. Amount excludes temporary equity. Alternate caption for the concept is permanent equity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 16 -URI http://asc.fasb.org/extlink&oid=108774443&loc=SL4568740-111683 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4I -URI http://asc.fasb.org/extlink&oid=84234705&loc=SL4590271-111686 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=108774443&loc=SL4568447-111683 + Details
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Data Type: | xbrli:monetaryItemType
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Period Type: | instant