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Acquisition of Txcell S.A. - Additional Information (Detail) |  | 3 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Oct. 01, 2018 USD ($) $ / shares shares | Dec. 31, 2018 USD ($) $ / shares shares | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2018 USD ($) $ / shares shares | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2018 € / shares | Oct. 01, 2018 € / shares | Jul. 20, 2018
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of free shares held by the holders | shares | 477,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Acquisition Number Of Vested Free Shares | shares | 453,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  | $ 26,837,000 | $ 23,562,000 | $ 21,416,000 | $ 12,637,000 | $ 13,077,000 | $ 11,812,000 | $ 8,253,000 | $ 3,425,000 | $ 84,452,000 | $ 36,567,000 | $ 19,389,000 |  |  |
Operating expenses |  | 47,609,000 | $ 39,803,000 | $ 40,556,000 | $ 33,634,000 | 26,843,000 | $ 24,847,000 | $ 21,021,000 | $ 20,217,000 | 161,602,000 | 92,928,000 | $ 91,948,000 |  |  |
Goodwill impairments |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |
Goodwill |  | $ 40,044,000 |  |  |  | $ 1,585,000 |  |  |  | 40,044,000 | $ 1,585,000 |  |  |  |
General and Administrative Expense [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Acquisition costs |  |  |  |  |  |  |  |  |  | $ 2,100,000 |  |  |  |  |
TxCell S.A. [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Acquisition date |  |  |  |  |  |  |  |  |  | Oct. 01, 2018 |  |  |  |  |
Number of ordinary shares acquired | shares | 13,519,036 | 11,528,635 |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of share capital and voting rights acquired |  | 98.20% |  |  |  |  |  |  |  | 98.20% |  |  |  |  |
Purchase price per share | (per share) | $ 2.99 | $ 2.94 |  |  |  |  |  |  |  | $ 2.94 |  |  | € 2.58 |  |
Estimated fair value of free shares | $ 200,000 |  |  |  |  |  |  |  |  | $ 1,300,000 |  |  |  |  |
Loan deemed to be part of purchase consideration | 5,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash paid to ordinary shares acquired | 40,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase consideration | $ 45,911,000 | $ 33,900,000 |  |  |  |  |  |  |  | $ 80,400,000 |  |  |  |  |
Revenues |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |
Operating expenses |  | $ 3,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value percentage at acquirer recognizes and consolidates assets acquired, liabilities assumed, and any non-controlling interest | 100.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares not purchased by the acquirer | shares | 11,981,867 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of remaining outstanding share owned by sellers | shares |  | 453,000 |  |  |  |  |  |  |  | 453,000 |  |  |  |  |
Goodwill impairment loss |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |  |
Goodwill | $ 38,995,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Changes in goodwill |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |  |
TxCell S.A. [Member] | IPR&D [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Identified intangible assets | $ 55,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
TxCell S.A. [Member] | SPA and TOA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of equity interests agreed to acquire |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100.00%
Number of free shares held by the holders | shares | 477,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase price per share | (per share) | $ 2.99 |  |  |  |  |  |  |  |  |  |  |  |  | € 2.58 |
Exchange rate on purchase price | 1.16 |  |  |  |  |  |  |  |  |  |  |  |  |  |
TxCell S.A. [Member] | SPA and TOA [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase price per share | € / shares |  |  |  |  |  |  |  |  |  |  |  |  |  | € 2.58 |
TxCell S.A. [Member] | SPA and TOA [Member] | Option Pricing Method [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated fair value of free shares | $ 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
TxCell S.A. [Member] | SPA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of ordinary shares acquired | shares | 13,519,036 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of share capital and voting rights acquired | 53.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |

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