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Acquisition of Txcell S.A. - Additional Information (Detail)
3 Months Ended 12 Months Ended
Oct. 01, 2018
USD ($)
$ / shares
shares
Dec. 31, 2018
USD ($)
$ / shares
shares
Sep. 30, 2018
USD ($)
Jun. 30, 2018
USD ($)
Mar. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Sep. 30, 2017
USD ($)
Jun. 30, 2017
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2018
USD ($)
$ / shares
shares
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2018
€ / shares
Oct. 01, 2018
€ / shares
Jul. 20, 2018
Business Acquisition [Line Items]                              
Number of free shares held by the holders | shares 477,000,000                            
Business Acquisition Number Of Vested Free Shares | shares 453,000,000                            
Revenues   $ 26,837,000 $ 23,562,000 $ 21,416,000 $ 12,637,000 $ 13,077,000 $ 11,812,000 $ 8,253,000 $ 3,425,000 $ 84,452,000 $ 36,567,000 $ 19,389,000      
Operating expenses   47,609,000 $ 39,803,000 $ 40,556,000 $ 33,634,000 26,843,000 $ 24,847,000 $ 21,021,000 $ 20,217,000 161,602,000 92,928,000 $ 91,948,000      
Goodwill impairments                   0          
Goodwill   $ 40,044,000       $ 1,585,000       40,044,000 $ 1,585,000        
General and Administrative Expense [Member]                              
Business Acquisition [Line Items]                              
Acquisition costs                   $ 2,100,000          
TxCell S.A. [Member]                              
Business Acquisition [Line Items]                              
Acquisition date                   Oct. 01, 2018          
Number of ordinary shares acquired | shares 13,519,036 11,528,635                          
Percentage of share capital and voting rights acquired   98.20%               98.20%          
Purchase price per share | (per share) $ 2.99 $ 2.94               $ 2.94     € 2.58    
Estimated fair value of free shares $ 200,000                 $ 1,300,000          
Loan deemed to be part of purchase consideration 5,200,000                            
Cash paid to ordinary shares acquired 40,500,000                            
Purchase consideration $ 45,911,000 $ 33,900,000               $ 80,400,000          
Revenues   0                          
Operating expenses   $ 3,700,000                          
Fair value percentage at acquirer recognizes and consolidates assets acquired, liabilities assumed, and any non-controlling interest 100.00%                            
Number of shares not purchased by the acquirer | shares 11,981,867                            
Number of remaining outstanding share owned by sellers | shares   453,000               453,000          
Goodwill impairment loss                   $ 0          
Goodwill $ 38,995,000                            
Changes in goodwill                   $ 0          
TxCell S.A. [Member] | IPR&D [Member]                              
Business Acquisition [Line Items]                              
Identified intangible assets $ 55,000,000                            
TxCell S.A. [Member] | SPA and TOA [Member]                              
Business Acquisition [Line Items]                              
Percentage of equity interests agreed to acquire                             100.00%
Number of free shares held by the holders | shares 477,000                            
Purchase price per share | (per share) $ 2.99                         € 2.58  
Exchange rate on purchase price 1.16                            
TxCell S.A. [Member] | SPA and TOA [Member] | Minimum [Member]                              
Business Acquisition [Line Items]                              
Purchase price per share | € / shares                           € 2.58  
TxCell S.A. [Member] | SPA and TOA [Member] | Option Pricing Method [Member]                              
Business Acquisition [Line Items]                              
Estimated fair value of free shares $ 200,000                            
TxCell S.A. [Member] | SPA [Member]                              
Business Acquisition [Line Items]                              
Number of ordinary shares acquired | shares 13,519,036                            
Percentage of share capital and voting rights acquired 53.00%