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Income Taxes - Schedule of Difference Between Benefit for Income Taxes and Federal Statutory Income Tax Rate (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Income Tax Disclosure [Abstract]
Tax at federal statutory rate	$ (14,467)	$ (18,553)	$ (24,369)
State taxes, net	(2,849)	795	(747)
Federal rate change		53,045
Foreign rate differential	(177)
Non-deductible stock-based compensation	(2,729)	2,120	2,781
Research credits	(1,005)	(869)	(1,424)
Change in valuation allowance	20,271	(36,575)	23,773
Other	$ 956	$ 37	(28)
Income tax benefit			$ (14)

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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