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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2019-05-08T17:45:39.4935493+00:00 -->
<!-- Version            : 3.4.7044.22220 -->
<!-- Package ID         : 3021686c338c4c68a36f62b741ac2a6d -->
<!-- Copyright (c) 2019 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="sgmo_AtTheMarketOfferingAgreementMember" name="AtTheMarketOfferingAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sgmo_CommonStockCapitalSharesValueReservedForFutureIssuance" name="CommonStockCapitalSharesValueReservedForFutureIssuance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="sgmo_BusinessAcquisitionPercentageOfEquityInterestsAgreedToAcquire" name="BusinessAcquisitionPercentageOfEquityInterestsAgreedToAcquire" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="sgmo_BusinessAcquisitionNumberOfSharesAcquired" name="BusinessAcquisitionNumberOfSharesAcquired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sgmo_SharePurchaseAgreementMember" name="SharePurchaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sgmo_BusinessAcquisitionExchangeRateOnPurchasePrice" name="BusinessAcquisitionExchangeRateOnPurchasePrice" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sgmo_BusinessAcquisitionRemainingNumberOfSharesOwnedBySellerUnderBlockTransaction" name="BusinessAcquisitionRemainingNumberOfSharesOwnedBySellerUnderBlockTransaction" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="sgmo_BusinessAcquisitionEstimatedFairValueLiabilitiesOfFreeShares" name="BusinessAcquisitionEstimatedFairValueLiabilitiesOfFreeShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="sgmo_BusinessAcquisitionEstimatedFairValueAssetsOfFreeShares" name="BusinessAcquisitionEstimatedFairValueAssetsOfFreeShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="sgmo_BusinessCombinationLoanAdjustedInPurchaseConsideration" name="BusinessCombinationLoanAdjustedInPurchaseConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="sgmo_BusinessAcquisitionEstimatedFairValueOfFreeShares" name="BusinessAcquisitionEstimatedFairValueOfFreeShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="sgmo_BusinessCombinationFairValuePercentageAtAcquirerRecognizesAndConsolidatedAssetsLiabilitiesAssumedAndNoncontrollingInterests" name="BusinessCombinationFairValuePercentageAtAcquirerRecognizesAndConsolidatedAssetsLiabilitiesAssumedAndNoncontrollingInterests" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="sgmo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInProcessResearchAndDevelopment" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInProcessResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="sgmo_BusinessAcquisitionNumberOfSharesOwnedBySellersUnderBlockTransaction" name="BusinessAcquisitionNumberOfSharesOwnedBySellersUnderBlockTransaction" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="sgmo_PostBusinessAcquisitionSharesAcquiredAmount" name="PostBusinessAcquisitionSharesAcquiredAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="sgmo_NoncontrollingInterestIncreaseDecreaseFromForeignCurrencyEffect" name="NoncontrollingInterestIncreaseDecreaseFromForeignCurrencyEffect" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
</xsd:schema>
