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Organization, Basis of Presentation and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended |  |  |
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Jun. 30, 2019 | Mar. 31, 2019 | Jun. 30, 2018 | Mar. 31, 2018 | Jun. 30, 2019 | Jun. 30, 2018 | Dec. 31, 2018 | Apr. 30, 2019 | Jan. 01, 2019 | Jan. 01, 2018
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Decrease in revenues | $ (17,548) |  | $ (21,416) |  | $ (25,619) | $ (34,053) |  |  |  |
Increase in net loss | 30,356 | $ 42,203 | $ 16,640 | $ 20,187 | 72,559 | $ 36,827 |  |  |  |
Accumulated deficit | $ (634,233) |  |  |  | (634,233) |  | $ (562,696) |  |  |
Topic 606 | Difference between Revenue Guidance in Effect before and after Topic 606 |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Accumulated deficit |  |  |  |  |  |  |  |  |  | $ 1,100
Topic 842 |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Accumulated deficit |  |  |  |  |  |  |  |  | $ (561,799) |
Topic 842 | Adjustments Due to the Adoption of ASC Topic 842 |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Accumulated deficit |  |  |  |  |  |  |  |  | $ 897 |
Intangible Assets |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Reclassification adjustment |  |  |  |  |  |  | $ 600 |  |  |
Pfizer |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Decrease in revenues |  |  |  |  | $ (25,600) |  |  |  |  |
Pfizer | Customer Concentration Risk | Total revenues |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Percentage of revenues | 26.00% |  | 38.00% |  | 16.00% | 47.00% |  |  |  |
Brammer |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Option deposit |  |  |  |  |  |  |  | $ 3,000 |  |
Option deposit, nonrefundable |  |  |  |  |  |  |  | 1,500 |  |
Kite Pharma Inc |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Decrease in revenues | $ (9,060) |  | $ (7,515) |  | $ (17,372) | $ (7,515) |  |  |  |
Kite Pharma Inc | Customer Concentration Risk | Total revenues |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Percentage of revenues | 52.00% |  | 35.00% |  | 18.00% | 22.00% |  |  |  |
Bioverativ Inc |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Decrease in revenues | $ (3,059) |  | $ (4,516) |  | $ (5,009) | $ (8,898) |  |  |  |
Bioverativ Inc | Customer Concentration Risk | Total revenues |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Percentage of revenues | 17.00% |  | 21.00% |  | 61.00% | 26.00% |  |  |  |
Collaboration Agreement | Pfizer |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Decrease in revenues |  |  |  |  | $ (3,000) |  |  |  |  |
Manufacturing Capability Establishment | Brammer |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Other commitment |  |  |  |  |  |  |  | $ 2,000 |  |
Change in Collaboration Agreement Scope | Collaboration Agreement | Pfizer |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Decrease in revenues |  |  |  |  | 3,000 |  |  |  |  |
Increase in net loss |  |  |  |  | $ 3,000 |  |  |  |  |
Increase in basic net loss per share (Usd per share) |  |  |  |  | $ 0.03 |  |  |  |  |

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