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Organization, Basis of Presentation and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended				6 Months Ended		12 Months Ended
	Jun. 30, 2019	Mar. 31, 2019	Jun. 30, 2018	Mar. 31, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018	Apr. 30, 2019	Jan. 01, 2019	Jan. 01, 2018
Organization And Summary Of Significant Accounting Policies [Line Items]
Decrease in revenues	$ (17,548)		$ (21,416)		$ (25,619)	$ (34,053)
Increase in net loss	30,356	$ 42,203	$ 16,640	$ 20,187	72,559	$ 36,827
Accumulated deficit	$ (634,233)				(634,233)		$ (562,696)
Topic 606 | Difference between Revenue Guidance in Effect before and after Topic 606
Organization And Summary Of Significant Accounting Policies [Line Items]
Accumulated deficit										$ 1,100
Topic 842
Organization And Summary Of Significant Accounting Policies [Line Items]
Accumulated deficit									$ (561,799)
Topic 842 | Adjustments Due to the Adoption of ASC Topic 842
Organization And Summary Of Significant Accounting Policies [Line Items]
Accumulated deficit									$ 897
Intangible Assets
Organization And Summary Of Significant Accounting Policies [Line Items]
Reclassification adjustment							$ 600
Pfizer
Organization And Summary Of Significant Accounting Policies [Line Items]
Decrease in revenues					$ (25,600)
Pfizer | Customer Concentration Risk | Total revenues
Organization And Summary Of Significant Accounting Policies [Line Items]
Percentage of revenues	26.00%		38.00%		16.00%	47.00%
Brammer
Organization And Summary Of Significant Accounting Policies [Line Items]
Option deposit								$ 3,000
Option deposit, nonrefundable								1,500
Kite Pharma Inc
Organization And Summary Of Significant Accounting Policies [Line Items]
Decrease in revenues	$ (9,060)		$ (7,515)		$ (17,372)	$ (7,515)
Kite Pharma Inc | Customer Concentration Risk | Total revenues
Organization And Summary Of Significant Accounting Policies [Line Items]
Percentage of revenues	52.00%		35.00%		18.00%	22.00%
Bioverativ Inc
Organization And Summary Of Significant Accounting Policies [Line Items]
Decrease in revenues	$ (3,059)		$ (4,516)		$ (5,009)	$ (8,898)
Bioverativ Inc | Customer Concentration Risk | Total revenues
Organization And Summary Of Significant Accounting Policies [Line Items]
Percentage of revenues	17.00%		21.00%		61.00%	26.00%
Collaboration Agreement | Pfizer
Organization And Summary Of Significant Accounting Policies [Line Items]
Decrease in revenues					$ (3,000)
Manufacturing Capability Establishment | Brammer
Organization And Summary Of Significant Accounting Policies [Line Items]
Other commitment								$ 2,000
Change in Collaboration Agreement Scope | Collaboration Agreement | Pfizer
Organization And Summary Of Significant Accounting Policies [Line Items]
Decrease in revenues					3,000
Increase in net loss					$ 3,000
Increase in basic net loss per share (Usd per share)					$ 0.03

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